Determination of the Prevalence and Prognostic Importance of Unrecognized Non-Q-wave Myocardial Infarction by MRI

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Duke University
ClinicalTrials.gov Identifier:
NCT00493168
First received: June 26, 2007
Last updated: May 24, 2013
Last verified: June 2007

June 26, 2007
May 24, 2013
January 1998
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Complete list of historical versions of study NCT00493168 on ClinicalTrials.gov Archive Site
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Determination of the Prevalence and Prognostic Importance of Unrecognized Non-Q-wave Myocardial Infarction by MRI
Unrecognized Non-Q-wave Myocardial Infarction: Prevalence, Angiographic Correlation, and Prognostic Significance in Patients With Suspected Coronary Disease

The first aim of this study is to determine how often unrecognized myocardial infarction occur in patients using a magnetic resonance imaging (MRI) technique (known as delayed enhancement MRI), as compared to the electrocardiogram. The second aim of this study is to determine the severity of coronary heart disease of the patients with unrecognized myocardial infarction. The final aim is to determine how the presence of unrecognized myocardial infarction detected by the MRI affects lifespan.

Unrecognized myocardial infarction (MI) is known to constitute a substantial portion of lethal coronary heart disease. However, since the diagnosis of unrecognized MI is based on the appearance of incidental Q-waves on 12-lead electrocardiography, the syndrome of unrecognized non-Q-wave MI has not been described. Delayed-enhancement cardiovascular magnetic resonance (DE-CMR) can accurately identify non-Q-wave MI. The aims of this study are three-fold: 1. to determine the prevalence of unrecognized non-Q-wave and Q-wave MI, 2. to define predictors of unrecognized non-Q-wave MI, 3. to determine the prognostic significance of unrecognized non-Q-wave MI.

Observational
Time Perspective: Prospective
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  • Coronary Arteriosclerosis
  • Myocardial Infarction
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Kim HW, Klem I, Shah DJ, Wu E, Meyers SN, Parker MA, Crowley AL, Bonow RO, Judd RM, Kim RJ. Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease. PLoS Med. 2009 Apr 21;6(4):e1000057. Epub 2009 Apr 21.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
185
November 2006
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Inclusion Criteria:

  • Patients with suspected coronary artery disease referred for invasive coronary angiography

Exclusion Criteria:

  • Clinical history of myocardial infarction
  • Percutaneous coronary intervention
  • Coronary artery bypass surgery
  • Known uncured malignancy
  • History of hypertrophic cardiomyopathy, myocarditis, or infiltrative heart disease
  • Contraindication of magnetic resonance imaging
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00493168
3434
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Duke University
Duke University
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Principal Investigator: Han W Kim, MD Duke Cardiovascular Magnetic Resonance Center
Principal Investigator: Raymond J Kim, MD Duke Cardiovascular Magnetic Resonance Center
Duke University
June 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP