Predictors for Pulmonary Valve Replacement - Anatomic and Hemodynamic Using MRI
|First Received Date ICMJE||June 19, 2007|
|Last Updated Date||December 10, 2013|
|Start Date ICMJE||September 2008|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures ICMJE||Not Provided|
|Original Primary Outcome Measures ICMJE||Not Provided|
|Change History||Complete list of historical versions of study NCT00489788 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures ICMJE||Not Provided|
|Original Secondary Outcome Measures ICMJE||Not Provided|
|Current Other Outcome Measures ICMJE||Not Provided|
|Original Other Outcome Measures ICMJE||Not Provided|
|Brief Title ICMJE||Predictors for Pulmonary Valve Replacement - Anatomic and Hemodynamic Using MRI|
|Official Title ICMJE||MRI Assessment of Right and Left Ventricular Strain, Associated Function, Volume and ECG Parameters as Predictors of Optimal Timing for Pulmonary Valve Replacement in Patients Post Repair for Tetralogy of Fallot|
Magnetic Resonance Imaging (MRI) is a non-invasive test that can look at the heart without using radiation. An MRI will allow the doctors to look at the heart in order to assess how well the ventricle is pumping, the amount of blood that it is pumping in addition to how much it is stretching. An engineer at Georgia Tech has developed a new way of looking at an MRI. It is believed that this new way of looking at an MRI may be better able to tell us when to replace the valve in these children. If this new process works, not only can we apply it now but we will be able to look at previously performed MRIs and gather more information about these children and their heart function in order to help these and other children in the future.
We are planning on enrolling 30 subjects in this study. Some of the subjects will be enrolled and have their MRI strictly for the purpose of this study. Some of the subjects will be already scheduled for a routine MRI of their heart and we will ask them if we can do extra images for the study while they are already here.
Cardiovascular disease remains a leading cause of morbidity and death in the Western World. Assessment of Myocardial function has proven to be a clinically relevant method for monitoring and evaluating outcomes of medical therapy and surgery for structural lesions or acquired disease.
Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease with a prevalence of 0.26 to 0.8 per 1000 live births The current surgical approach favors primary repair in infancy. This decreases the necessity for palliative procedures and has a low operative mortality. Complete repair often results in pulmonary regurgitation (PR), which is generally well tolerated in infancy. Late complications may include ventricular dilatation, tricuspid regurgitation, diastolic and systolic dysfunction, arrhythmias and sudden cardiac death.
Pulmonary valve replacement (PVR) is required in approximately 20% of patients with repaired TOF and has a 1-4% peri-operative mortality. Thus, early intervention may reduce irreversible right ventricle injury; however no definitive tools are presently available for determining patients at risk.
Myocardial strain analysis has not been critically evaluated to determine its value for predicting RV failure. This study will investigate the practicality and accuracy of a novel mathematical method, developed by the investigators, for analysis of cardiac deformation recovery from dynamic Cardiovascular Magnetic Resonance Imaging (CMRI) sequences. The proposed method requires structural MRI data, offering several important advantages over existing methods. These include reduced requirements in imaging time and analysis effort, and the option to use a large database of prior structural MRI studies of TOF patients in retrospective research.
This three-dimensional method is mathematically based on nearly incompressible tissue deformations. The project proposes validation of technique, comparing its results with current 'gold standard' methods that presently use CMRI myocardial tagging and phase velocity mapping, as a pilot study for clinical validation of strain imaging in TOF patients. The method tracks movement of myocardial tissue throughout the cardiac cycle to compute strain associated with normal and a clinical disease state.
During the study we will customize the method and software for specific use with CMRI and TOF. We will test the method on normal controls and TOF patients pre and post pulmonary valve replacement.
|Study Type ICMJE||Observational|
|Study Design ICMJE||Observational Model: Cohort
Time Perspective: Prospective
|Target Follow-Up Duration||Not Provided|
|Sampling Method||Non-Probability Sample|
Pediatrics and young adults aged 3-30 years following surgical repair of Tetralogy of Fallot. Also looking at normal control subjects.
|Condition ICMJE||Congenital Disorders|
|Intervention ICMJE||Not Provided|
|Study Group/Cohort (s)||Not Provided|
|Publications *||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status ICMJE||Completed|
|Completion Date||March 2009|
|Primary Completion Date||Not Provided|
|Eligibility Criteria ICMJE||
|Ages||3 Years to 30 Years|
|Accepts Healthy Volunteers||Yes|
|Contacts ICMJE||Contact information is only displayed when the study is recruiting subjects|
|Location Countries ICMJE||Not Provided|
|NCT Number ICMJE||NCT00489788|
|Other Study ID Numbers ICMJE||IRB00000990|
|Has Data Monitoring Committee||No|
|Responsible Party||W. James Parks, MD, Emory University|
|Study Sponsor ICMJE||Emory University|
|Collaborators ICMJE||Children's Healthcare of Atlanta|
|Information Provided By||Emory University|
|Verification Date||December 2013|
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP