Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients

This study has been completed.
Sponsor:
Information provided by:
Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier:
NCT00485706
First received: June 12, 2007
Last updated: January 15, 2010
Last verified: June 2007

June 12, 2007
January 15, 2010
June 2007
Not Provided
  • correlation between calcium increase and pulse wave velocity
  • correlation between calcium change and pth change
Same as current
Complete list of historical versions of study NCT00485706 on ClinicalTrials.gov Archive Site
  • correlation between calcium increase and vascular calcifications
  • correlation between calcium change and bone markers
Same as current
Not Provided
Not Provided
 
Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients

Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease.

In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.

Study hypothesis.

Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium.

This may result in higher extraosseous calcification and higher pulse wave velocity

∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"

Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
  • Kidney Disease
  • Hypercalcemia
Procedure: high calcium dialysate
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
Not Provided
Not Provided

Inclusion Criteria:

  • maintenance hemodialysis patients

Exclusion Criteria:

  • dialysis <3 months
  • aortobifemoral graft
  • calcium level predialysis >10.5 mg/dl
Both
18 Years to 75 Years
No
Contact information is only displayed when the study is recruiting subjects
Belgium
 
NCT00485706
ML4181, S50455
No
Not Provided
Universitaire Ziekenhuizen Leuven
Not Provided
Principal Investigator: kathleen Claes, MD UZ Gasthuisberg
Universitaire Ziekenhuizen Leuven
June 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP