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fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease (ALZ)
This study is enrolling participants by invitation only.
Study NCT00478491   Information provided by University of Wisconsin, Madison
First Received: May 22, 2007   Last Updated: May 26, 2009   History of Changes

May 22, 2007
May 26, 2009
January 2003
 
 
 
Complete list of historical versions of study NCT00478491 on ClinicalTrials.gov Archive Site
 
 
 
fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease
fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

 
 
Observational
Case Control, Prospective
  • Magnetic Resonance Imaging
  • Alzheimer's Disease
  • Dementia
  • Adult Children
  • Risk
 
  • Persons with a parent with Alzheimer's disease
  • Persons whose parents survived to old age without memory problems
  • Persons with diagnosed mild cognitive impairment
  • Persons without memory problems

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Enrolling by invitation
390
July 2009
 

Inclusion Criteria:

  • MCI Group: Diagnosis of mild cognitive impairment
  • AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
  • Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion Criteria:

  • Claustrophobia
  • Metallic or electronic implants or devices that are not MRI-safe
Both
40 Years to 85 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00478491
Sterling Johnson, PhD, University of Wisconsin - Madison
2002-515, NIH RO1 AG021155A
University of Wisconsin, Madison
  • National Institutes of Health (NIH)
  • National Institute on Aging (NIA)
Principal Investigator: Sterling C Johnson, PhD University of Wisconsin/VA GRECC
University of Wisconsin, Madison
November 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP