fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease - Tabular View

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fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease (ALZ)

This study is enrolling participants by invitation only.
Information provided by University of Wisconsin, Madison

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Official Title ^†

fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Brief Summary

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Detailed Description

Study Phase

Study Type ^†

Observational

Study Design ^†

Case Control, Prospective

Primary Outcome Measure ^†

Secondary Outcome Measure ^†

Condition ^†

Magnetic Resonance Imaging
Alzheimer's Disease
Dementia
Adult Children
Risk

Intervention ^†

MEDLINE PMIDs

17445294, 16738250, 16412236, 16321166, 16102979

Links

Website for the Sterling Johnson Imaging Lab This link exits the ClinicalTrials.gov site

Website for the Wisconsin Comprehensive Memory Program This link exits the ClinicalTrials.gov site

Recruitment Information Fields

Recruitment Status ^†

Enrolling by invitation

Enrollment ^†

390

Start Date ^†

January 2003

Completion Date

July 2009

Eligibility Criteria ^†

Inclusion Criteria:

MCI Group: Diagnosis of mild cognitive impairment
AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion Criteria:

Claustrophobia
Metallic or electronic implants or devices that are not MRI-safe

Gender

Both

Ages

40 Years to 85 Years

Accepts Healthy Volunteers

Yes

Contacts ^††

Location Countries ^†

United States

Administrative Information Fields

NCT ID ^†

NCT00478491

Organization ID

2002-515

Secondary IDs ^††

NIH RO1 AG021155A

Study Sponsor ^†

University of Wisconsin, Madison

Collaborators ^††

National Institutes of Health (NIH)
National Institute on Aging (NIA)

Investigators ^†

Principal Investigator:

Sterling C Johnson, PhD

University of Wisconsin/VA GRECC

Information Provided By

University of Wisconsin, Madison

Verification Date

December 2007

First Received Date ^†

May 22, 2007

Last Updated Date

December 19, 2007

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.