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| Descriptive Information Fields | |||||
| Brief Title † | fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease | ||||
| Official Title † | fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease | ||||
| Brief Summary | The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors. |
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| Detailed Description | |||||
| Study Phase | |||||
| Study Type † | Observational | ||||
| Study Design † | Case Control, Prospective | ||||
| Primary Outcome Measure † | |||||
| Secondary Outcome Measure † | |||||
| Condition † | Magnetic Resonance Imaging Alzheimer's Disease Dementia Adult Children Risk |
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| Intervention † | |||||
| MEDLINE PMIDs | 17445294, 16738250, 16412236, 16321166, 16102979 | ||||
| Links | Website for the Sterling Johnson Imaging Lab ![]() Website for the Wisconsin Comprehensive Memory Program  ![]() |
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| Recruitment Information Fields | |||||
| Recruitment Status † | Enrolling by invitation | ||||
| Enrollment † | 390 | ||||
| Start Date † | January 2003 | ||||
| Completion Date | July 2009 | ||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||
| Ages | 40 Years to 85 Years | ||||
| Accepts Healthy Volunteers | Yes | ||||
| Contacts †† | |||||
| Location Countries † | United States | ||||
| Administrative Information Fields | |||||
| NCT ID † | NCT00478491 | ||||
| Organization ID | 2002-515 | ||||
| Secondary IDs †† | NIH RO1 AG021155A | ||||
| Study Sponsor † | University of Wisconsin, Madison | ||||
| Collaborators †† | National Institutes of Health (NIH) National Institute on Aging (NIA) |
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| Investigators † |
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| Information Provided By | University of Wisconsin, Madison | ||||
| Verification Date | December 2007 | ||||
| First Received Date † | May 22, 2007 | ||||
| Last Updated Date | December 19, 2007 | ||||