fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease - Tabular View

Tracking Information

First Received Date ^ICMJE

May 22, 2007

Last Updated Date

May 26, 2009

Start Date ^ICMJE

January 2003

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00478491 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Official Title ^ICMJE

fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Brief Summary

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Detailed Description

Study Phase

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Case Control, Prospective

Condition ^ICMJE

Magnetic Resonance Imaging
Alzheimer's Disease
Dementia
Adult Children
Risk

Intervention ^ICMJE

Study Arms / Comparison Groups

Persons with a parent with Alzheimer's disease
Persons whose parents survived to old age without memory problems
Persons with diagnosed mild cognitive impairment
Persons without memory problems

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Enrolling by invitation

Estimated Enrollment ^ICMJE

390

Estimated Completion Date

July 2009

Primary Completion Date

Eligibility Criteria ^ICMJE

Inclusion Criteria:

MCI Group: Diagnosis of mild cognitive impairment
AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion Criteria:

Claustrophobia
Metallic or electronic implants or devices that are not MRI-safe

Gender

Both

Ages

40 Years to 85 Years

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

United States

Administrative Information

NCT ID ^ICMJE

NCT00478491

Responsible Party

Sterling Johnson, PhD, University of Wisconsin - Madison

Study ID Numbers ^ICMJE

2002-515, NIH RO1 AG021155A

Study Sponsor ^ICMJE

University of Wisconsin, Madison

Collaborators ^ICMJE

National Institutes of Health (NIH)
National Institute on Aging (NIA)

Investigators ^ICMJE

Principal Investigator:

Sterling C Johnson, PhD

University of Wisconsin/VA GRECC

Information Provided By

University of Wisconsin, Madison

Verification Date

November 2008

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP