Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease (PC)

This study has been completed.
Sponsor:
Collaborator:
Information provided by:
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
NCT00478166
First received: May 22, 2007
Last updated: April 12, 2011
Last verified: April 2011

May 22, 2007
April 12, 2011
July 2005
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00478166 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease
Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease

The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate. Determining the functionality of this brain region may help us diagnose AD more accurately, thus allowing earlier treatment.

The posterior cingulate is a key brain region suggested by recent studies to be affected in people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the course of AD and the region may have reduced function even prior to the onset of symptoms, further understanding of its functional role and its relationship to other brain regions may be helpful in detecting AD earlier and in monitoring disease progression and treatment. This project examines the role of the PC and its connections to other brain regions using functional magnetic resonance imaging (fMRI), a technique that allows us to examine the brain at work during tests of memory and decision-making. The main goal is to see if functional connections between brain regions are modulated by risk for AD.

Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

People who are enrolled in the Wisconsin Registry for AD Prevention (WRAP), recruited from Memory clinics and the community.

  • Magnetic Resonance Imaging
  • Alzheimer's Disease
  • Dementia
  • Adult Children
  • Risk
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
206
October 2007
Not Provided

Inclusion Criteria:

  • Cognitively healthy
  • (Controls Only) Parents survived past age 70 and did/do not have memory problems.

Exclusion Criteria:

  • Claustrophobia
  • Metallic or electronic implants
Both
55 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00478166
2004-174
Yes
Sterling Johnson, PhD, University of Wisconsin - Madison
University of Wisconsin, Madison
Department of Veterans Affairs
Principal Investigator: Sterling C Johnson, PhD University of Wisconsin/VA GRECC
University of Wisconsin, Madison
April 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP