The goal of this research study is to collect blood and tissue samples and clinical data from patients with untreated newly diagnosed inflammatory breast cancer (IBC). The blood and tissue samples and clinical data will be stored in a research tissue bank and used to help researchers try to better understand IBC.

IBC:

Inflammatory breast cancer (IBC) is a rare but rapidly growing form of breast cancer. Currently, there are no known risk factors and biological features (such as in the genes) that researchers can use to help design better treatments for IBC.

Study Participation:

Participants in this study will be identified at the time of their first visit to M. D. Anderson. If you agree to take part in this study, you will have the following tests/procedures performed.

• You will have additional blood (about 4 tablespoons) drawn for this study, during a routine blood draw.
• You will have a core, breast tissue, and skin biopsy. If lymph nodes are noticed during the core biopsy, lymph nodes core biopsy or final needle aspiration will be done as well. To perform a core, breast tissue, and skin biopsy, an affected area of skin is numbed with anesthetic, and a small amount of skin tissue is removed with a small knife. This is a fresh sample collected for diagnosis and for the study.
• You will have an interview. During this interview, you will be asked questions about your medical history as well as general background information. The interview will be conducted by the study chair or their designee in the examination room and after the meeting with the physician in a private setting. The interview will take about 30 minutes to complete. Language Assistance will be called if a participant is non-English speaking.
• Your clinical data will be collected from your medical record, including information about your blood and tumor tissue samples and information from the magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) scans you may have had.
• Photos of both breasts will be taken.

Length of Study:

Your participation in this study will be complete after your samples and data are collected.

Research Tissue Bank:

Before your blood and tissue samples and information can be used for research, the people doing the research must get specific approval from the Institutional Review Board (IRB) of M. D. Anderson. The IRB is a committee made up of doctors, researchers, and members of the community. The IRB is responsible for protecting the participants involved in research studies and making sure all research is done in a safe and ethical manner. All research done at M. D. Anderson, including research involving your samples and information from this bank, must first be approved by the IRB.

This is an investigational study. Up to 300 patients will take part in this study. Up to 150 will be enrolled at M.D. Anderson.

• Other: Interview
  Personal Interview
• Procedure: Blood and Tissue Collection
  Blood (about 4 tablespoons) collected during routine blood draw, breast tissue collected at the time of standard diagnostic procedure, and a core and a skin biopsy collected at the time of standard diagnostic procedure.

Inclusion Criteria:

1. Patients with new clinical diagnosis of primary inflammatory breast cancer (IBC)
2. Histological diagnosis of invasive breast cancer
3. No previous or current treatment for newly diagnosed IBC
4. Age > 18 years
5. Able to provide informed consent

Exclusion Criteria:

1) Secondary IBC