Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00476372
First received: May 21, 2007
Last updated: January 11, 2013
Last verified: January 2013

May 21, 2007
January 11, 2013
August 2007
December 2011   (final data collection date for primary outcome measure)
cognitive measures [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00476372 on ClinicalTrials.gov Archive Site
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Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms
Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms -the Relation Between Cognitive Deficits and Comorbid Psychiatric Disorders, Medication, and Age at Disease Onset

Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive impairments. There is a lack of consensus as to the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the type and severity of cognitive impairment. This discrepancy can in part be caused by the lack of distinction between patients with different motor symptoms and disease severity.

Objective: To identify the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the severity and type of cognitive dysfunction in patients with idiopathic PD categorized according to motor symptoms and disease severity.

Methods: the population of patients with PD in the old county of Aarhus is described on the background of medical records, and stratified in accordance to age, sex and cardinal symptoms. Through proportional allocation a sample of a minimum of 50 patients with PD is drawn from the population. The patients and 30 healthy matched controls will undergo comprehensive neuropsychological assessment including tests of language, memory, executive function, and visuospatial function. Furthermore, all participants will be screened for depression (Geriatric Depression Scale) and psychiatric symptoms (Neuropsychiatric Inventory and Symptom Checklist). The patients will be categorized in accordance with their motor symptoms via cluster analysis for the purpose of analyzing the effect of psychiatric symptoms, depression, and age of disease onset, disease duration, and medication on cognition.

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Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
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Non-Probability Sample

77 patients with PD and 30 healthy control participants

Parkinson's Disease
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Parkinson's disease
Pt with parkinsons disease
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
107
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Idiopathic Parkinson's in accordance to UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria,
  • Born and raised in Denmark ,
  • >50 years

Exclusion Criteria:

  • Cerebrovascular disease,
  • Dementia not caused by Parkinson's Disease,
  • Metabolism anomaly,
  • Abuse of drugs, medication or alcohol,
  • History of head injuries,
  • Severe psychiatric disorder, excluding depression,
  • Resident outside the region of Aarhus h) DBS -
Both
50 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00476372
UAarhus
No
University of Aarhus
University of Aarhus
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Study Chair: Karen Østergaard, neurologist Aarhus Universitetshospital
Study Chair: Lars Larsen, MSc, PhD, Associate Professor The Institute of Psychology
University of Aarhus
January 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP