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Preoperative NSAID to Colorectal Cancer Patients

This study has been completed.
Information provided by Göteborg University

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Descriptive Information Fields
Brief Title  Preoperative NSAID to Colorectal Cancer Patients
Official Title  Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions
Brief Summary

The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer.

Detailed Description

Study and control patients are randomized to receive preoperative treatment with indomethacin or celecoxib compared to sham treatment.Tumor biopsies are taken at operation and used for analyses of tumor immunity and gene expression.

Study Phase Phase IV
Study Type  Interventional
Study Design  Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Primary Outcome Measure  Immune reactivity [ Time Frame: Acute evaluations ]
Secondary Outcome Measure 
Condition  Colorectal Cancer
Intervention  Drug: Indomethacin, celecoxib, esomeprazole
MEDLINE PMIDs
Links Göteborg University This link exits the ClinicalTrials.gov site
Recruitment Information Fields
Recruitment Status  Completed
Enrollment  28
Start Date  December 1998
Completion Date May 2007
Eligibility Criteria 

Inclusion Criteria:

  • Colon carcinoma scheduled for curative operation

Exclusion Criteria:

  • Diabetes, steroid medication, liver and kidney impairment
Gender Both
Ages 40 Years to 80 Years
Accepts Healthy Volunteers No
Contacts ††
Location Countries  Sweden
Administrative Information Fields
NCT ID  NCT00473980
Organization ID kl4501122
Secondary IDs ††
Study Sponsor  Göteborg University
Collaborators ††
Investigators 
Principal Investigator:     Kent Lundholm, MD, prof     Göteborg University    
Information Provided By Göteborg University
Verification Date May 2007
First Received Date  May 15, 2007
Last Updated Date May 15, 2007

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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