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Older Adult Training Study With Creatine and CLA (OTR)

This study has been completed.
Sponsor:
Information provided by:
McMaster University
ClinicalTrials.gov Identifier:
NCT00473902
First received: May 15, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted

May 15, 2007
May 15, 2007
August 2003
Not Provided
a. Muscle and bone mass b. Knee extension strength e. Creatine content f. Muscle oxidative capacity g. Aerobic power (oxygen consumption) [ Time Frame: six months ]
Same as current
No Changes Posted
a. Functional capacity b. Strength with weight machines [ Time Frame: six months ]
Same as current
Not Provided
Not Provided
 
Older Adult Training Study With Creatine and CLA
Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (> 65 y). Our study hypothesized that administering CrM and CLA would yield greater strength and body composition benefits than the placebo group over the six months of resistance exercise

Men (N=19) and women (N=20) completed six months of resistance exercise training with Creatine Monohydrate (5g/d) + Conjugated Linoleic Acid (6g/d) or placebo with randomized, double-blind, allocation.Outcomes included; strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Ν-telopeptides).
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Prevention
Sarcopenia
  • Behavioral: Training
  • Drug: Creatine Monohydrate, Conjugated Linoleic Acid
Not Provided
Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, Pearce E, Roy B, Doherty T. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS ONE. 2007 Oct 3;2(10):e991.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
39
September 2004
Not Provided

Inclusion Criteria:

  • Healthy,
  • Ambulatory,
  • Recreationally active,
  • Community dwelling

Exclusion Criteria:

  • Evidence of coronary heart disease;
  • Congestive heart disease;
  • Uncontrolled hypertension;
  • Chronic obstructive pulmonary disease;
  • Diabetes mellitus;
  • Renal failure;
  • Major orthopedic disability; and
  • Smoking
Both
65 Years to 85 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Canada
 
NCT00473902
Older Adult Training Study
No
Not Provided
Hamilton Health Sciences Corporation
Not Provided
Principal Investigator: Mark A Tarnopolsky, M.D., Ph.D. McMaster University
McMaster University
May 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP