The Effect of Calcium on Postprandial Lipid Profile and Appetite

This study has been completed.
Sponsor:
Collaborators:
Arla Foods
The Danish Dairy Research Foundation, Denmark
FOOD Graduate School, the Royal Veterinary & Agricultural University, Denmark
Danish Research Agency
Dutch Dairy Organization (NZO)
Pharna Vinci, Denmark
Information provided by:
University of Copenhagen
ClinicalTrials.gov Identifier:
NCT00464035
First received: April 19, 2007
Last updated: January 20, 2009
Last verified: December 2004

April 19, 2007
January 20, 2009
February 2005
Not Provided
Postprandial changes in: total plasma triacylglyceride; Chylomicron triacylglyceride; Cholesterol
Same as current
Complete list of historical versions of study NCT00464035 on ClinicalTrials.gov Archive Site
Postprandial changes in:insulin; glucose; CCK; Ghrelin; GLP-1, appetite measured by visual analogue scales, BCAA
Same as current
Not Provided
Not Provided
 
The Effect of Calcium on Postprandial Lipid Profile and Appetite
Not Provided

The purpose of this study is to investigate the effect of calcium on postprandial lipid profile and appetite.

Several reports have found inverse associations between calcium intake and body weight. Intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. In addition, it seems that calcium from dairy products have a more profound effect than calcium from supplements. The mechanism of this additional dairy effect is not yet clear, but one possible explanation could be reduced absorption of fat in the gut. The increase in fecal fat excretion on a high calcium diet could be due to the formation of calcium-fatty acid soaps in the gut.

The long term effect of a high calcium intake have been under intense investigation, but as far as we know the acute effect of a high calcium intake have not yet been examined. A study concerning the acute effects could help us understand the effect of calcium on the absorption of fat. After a meal triglyceride (TG) is packaged with cholesterol, lipoproteins and other lipids into particles called chylomicrons. Earlier studies have shown that the fatty acid pattern of chylomicron lipids postprandial was very similar to that of the ingested fat. If we assume that calcium inhibits the absorption of fat, we would expect a reduced total plasma triglyceride concentration after a calcium-rich meal.

Appetite involves many different sensations among which hunger and satiety are the most investigated. Several different hormones are involved in the regulation of appetite. Some of these hormones are known to respond to the intake or absorption of fat. If the absorption of fat is inhibited the regulation of appetite most likely will be affected. In the long term this could be important because an increased appetite probably would increase energy intake and thereby reducing the weight loss we otherwise might have accomplished by the reduced absorption of fat.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Obesity
Behavioral: high calcium intake
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
18
October 2005
Not Provided

Inclusion Criteria:

  • healthy meals
  • BMI 24-31 kg/m2
  • age between 18-50 years
  • hemoglobin >8 mmol/L

Exclusion Criteria:

  • donation of blood 6 months before and under the study
  • milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
  • use of dietary supplements 3 months before and under the study
  • smoking
  • elite athletes
  • use of medication
Male
18 Years to 50 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00464035
KF 01-144/02
Not Provided
Not Provided
University of Copenhagen
  • Arla Foods
  • The Danish Dairy Research Foundation, Denmark
  • FOOD Graduate School, the Royal Veterinary & Agricultural University, Denmark
  • Danish Research Agency
  • Dutch Dairy Organization (NZO)
  • Pharna Vinci, Denmark
Principal Investigator: Arne Astrup, Prof. Dr. Institute of Human Nutrition, the Royal Veterinary & Agricultural University, Denmark
University of Copenhagen
December 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP