A Comparison of Mometasone to Advair in Patients With Milder Persistent Asthma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by Johns Hopkins University.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Schering-Plough
Information provided by:
Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT00461812
First received: April 16, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted

April 16, 2007
April 16, 2007
April 2007
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No Changes Posted
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A Comparison of Mometasone to Advair in Patients With Milder Persistent Asthma
A Single-Blind, Randomized, Positive-Controlled Study to Compare Monotherapy With an Inhaled Corticosteroid (Mometasone) to Combination Therapy With an Inhaled Corticosteroid + a Long-Acting Bronchodilator (Advair) in Patients With Milder Persistent Asthma

The research hypothesis for the proposed study asks the question, can Asmanex® demonstrate comparable anti-inflammatory therapeutic efficacy to the combination product, Advair® in control of mild persistent asthma?

The purpose is to demonstrate that the anti-inflammatory protection afforded by monotherapy with an inhaled steroid (Asmanex®) is comparable to combination therapy with Advair® 100/50, when measured by this standard methodology (methacholine bronchoprovocation) in subjects with mild persistent asthma.

Not Provided
Interventional
Phase 4
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
Asthma
Drug: Mometasone or Advair
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
45
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Inclusion Criteria:

  • subjects 18 to 65 years of age
  • a >2 year history of asthma
  • FEV1 > 80% for subjects currently using Advair®.

Exclusion Criteria:

  • severe asthma
  • current smokers
  • pregnant or breast-feeding women
  • other chronic significant illnesses
Both
18 Years to 65 Years
No
Contact: Arouna P Khattignavong, MD 410-550-2184 akhatti1@jhmi.edu
Contact: Susan L Balcer Whaley, MPH 410-550-2122 swhaley1@jhmi.edu
United States
 
NCT00461812
NA_00001154
Yes
Not Provided
Johns Hopkins University
Schering-Plough
Principal Investigator: Peter S Creticos, MD Johns Hopkins University
Johns Hopkins University
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP