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Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma
This study is ongoing, but not recruiting participants.
Study NCT00459849   Information provided by Barnes Retina Institute
First Received: April 11, 2007   Last Updated: May 6, 2008   History of Changes

April 11, 2007
May 6, 2008
July 2000
July 2007   (final data collection date for primary outcome measure)
  • Plaque tilt using intraoperative ultrasonography [ Time Frame: End of study ] [ Designated as safety issue: No ]
  • Local melanoma failure [ Time Frame: End of study ] [ Designated as safety issue: No ]
  • Plaque tilt using intraoperative ultrasonography
  • Local melanoma failure
Complete list of historical versions of study NCT00459849 on ClinicalTrials.gov Archive Site
 
 
 
Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma
Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma

Plaque radiotherapy is a common treatment for uveal melanoma. However, local failure has been reported in up to 20% of patients. We use intraoperative ultrasonography at plaque insertion and removal to evaluate plaque movement as a potential factor in local failure.

Episcleral plaque radiotherapy is a common treatment for uveal melanoma and results in local tumor control in most cases. However, local failure has been reported in a substantial proportion of patients. Since local failure greatly increases the risk of metastatic death, identifying and correcting the causes of local treatment failure are of paramount importance. Poor plaque localization is an important contributing factor to local failure. With the aid of intraoperative ultrasonography, most malpositioned plaques can be identified and readjusted at the time of plaque insertion. However, little is known about plaque movement during the 4-5 days of brachytherapy, which could also contribute to local failure. To address this question, we perform intraoperative B-scan ultrasonography at the time of iodine-125 radioactive plaque insertion and removal in uveal melanoma patients.

 
Interventional
Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study
Uveal Melanoma
Procedure: Intraoperative ultrasonography
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Active, not recruiting
175
July 2007
July 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • All patients with uveal melanoma treated with brachytherapy

Exclusion Criteria:

  • Ciliary melanoma
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00459849
Archavan Almony, M.D., Barnes Retina Institute
HRPO# 07-0092
Barnes Retina Institute
 
Principal Investigator: J W Harbour, MD Washington University School of Medicine
Barnes Retina Institute
May 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP