Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children (ALTAC)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by Liverpool School of Tropical Medicine.
Recruitment status was  Not yet recruiting
Sponsor:
Collaborator:
Thrasher Research Fund
Information provided by:
Liverpool School of Tropical Medicine
ClinicalTrials.gov Identifier:
NCT00456469
First received: April 4, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted

April 4, 2007
April 4, 2007
May 2007
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No Changes Posted
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Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children
Diagnosis of Active and Latent TB Infection With IFN-y Assays in African Children

Study based in Southern Ethiopia Purpose - to explore if children in contact with adults with TB have positive acute reactants such as IFN-y and other cytokine responses; if these responses discriminate between high and low risk of disease progression and whether these could be incorporated into improved diagnostic approaches.

The study follows children in contact with TB. Those with positive TST will be offered chemoprophylaxis and all children will be followed for 2 years to describe IFN-y responses over time, identify symptoms of active TB and if these symptoms are associated with IFN-y and other cytokine responses.

Children with suspicion of TB attending health centres will also be investigated using routine diagnostic tests and IFN-y and other cytokines responses to evaluate if the latter could be used in improved diagnostic approaches.

Observational
Observational Model: Defined Population
Time Perspective: Longitudinal
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Tuberculosis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
500
October 2009
Not Provided

Inclusion Criteria:

- Children - 1 to 14 years old in contact with adults with smear positive TB

Or:

- Children with suspicion of TB admitted to the hospital for investigations

Exclusion Criteria:

- Residency > 10 Km from recruitment center

Or:

- Patient severely to undergo diagnostic procedures.

Both
1 Year to 14 Years
No
Contact: Luis Cuevas, MD MTropMed 0151 705 3219 lcuevas@liv.ac.uk
Ethiopia
 
NCT00456469
06.49 TF Cuevas
Yes
Not Provided
Liverpool School of Tropical Medicine
Thrasher Research Fund
Principal Investigator: Luis Cuevas, Dr Liverpool School of Tropical Medicine
Liverpool School of Tropical Medicine
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP