• Rate of auditory changes following 3 days of treatment with artemether-lumefantrine at Days 7, 28, and 42 days assessed by pure tone thresholds assessments (a type of hearing test)
• Changes in auditory function with other antimalarial agents assessed by pure tone thresholds assessments (a type of hearing test)
• Relationship between changes in auditory function and drug exposure

To evaluate the potential effects of artemether- lumefantrine on the auditory function

• Malaria
• Falciparum

• Drug: artesunate-mefloquine
• Drug: atovaquone-proguanil
• Drug: Artemether-lumefantrine
  Artemether-lumefantrine
  Other Names:

  • Coartem
  • Malarone

• 1: Experimental
  Intervention: Drug: Artemether-lumefantrine
• 2: Active Comparator
  Intervention: Drug: atovaquone-proguanil
• 3: Active Comparator
  Intervention: Drug: artesunate-mefloquine

Inclusion Criteria 12 years of age or older P. falciparum parasitemia between 1,000 and 100,000 parasites/μl History of fever or presence of fever (temperature ≥ 37.5°C)

Exclusion Criteria Signs/symptoms of severe/complicated malaria Ingestion of various antimalarial drugs, or antibiotics in the previous 2 weeks to 2 months History of any drug-related hearing impairment. Abnormal hearing function at study entry Exposure to sustained loud noises, by self-report, within the past 24 hours. Present ear problems Pregnant or lactating (urine test for β-HCG) to be performed on any woman of child bearing age) Other protocol-defined inclusion/exclusion criteria may apply.