• Retinoid irritation symptoms [ Time Frame: Weeks 6, 8, 12, 16, 20 and 24 ] [ Designated as safety issue: No ]
• Improvement of sun-damage (wrinkling, uneven skin color, roughness and brown spots). [ Time Frame: At the end of the study (week 24) ] [ Designated as safety issue: No ]

• Retinoid irritation symptoms
• Improvement of sun-damage (wrinkling, uneven skin color, roughness and brown spots).

Sun-damaged skin, caused by chronic exposure to ultraviolet (UV) light, is characterized by features such as wrinkling, uneven skin color, roughness and brown spots. An effective treatment for sun-damage that is commonly prescribed is topical retinoic acid (RA). However, the major drawback of topical RA use has been frequently observed irritation characterized by redness, dry skin and severe itching. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to RA treatment.

Sun-damaged skin, caused by chronic exposure to ultraviolet (UV) light, is characterized by features such as wrinkling, uneven skin color, roughness and brown spots. An effective treatment for sun-damage that is commonly prescribed is topical retinoic acid. However, the major drawback of topical retinoic acid use has been frequently observed irritation characterized by redness, dry skin and severe itching. In this study, we examine whether a daily skin care regimen comprised of an ultra mild cleanser and an effective moisturizer can help improve tolerance to retinoid treatment.

Subjects for whom retinoid treatment is indicated for sun-damage will be recruited into the study. The retinoid intolerance will be established via prior history (detailed questionnaire) and a 2-week retinoid treatment (Tazarotene 0.1% cream) phase followed by clinical evaluation and determination of retinoid intolerance.

Subjects that exhibit retinoid intolerance will continue with the study. Approximately 30 subjects will be put on a controlled daily skin care regimen during the remainder of the study period while the rest of the subjects will continue their normal skin care habits. The controlled skin care regimen will consist of facial cleansing with a Dove ultra mild emollient cleanser and application of Dove facial moisturizer, used as normal. During this period, subjects will be evaluated to determine reduction of retinoid intolerance symptoms.

• Sun-Damaged Skin
• Retinoid Intolerance

• Drug: Tazorac
• Drug: Dove Mild Cleanser
• Drug: Dove Facial Moisturizer

Inclusion Criteria:

• Caucasians between the ages of 40 and 90 with moderate to severe sun-damage on the face who are generally healthy may participate.
• You must demonstrate a previous history of retinoid intolerance (established through prior history and the 2-week retinoid treatment phase of this study).
• Women of childbearing potential must agree to use an accepted form of birth control for the entire duration of the study.
• You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be able to attend all of the scheduled appointments during the study.

Exclusion Criteria:

• You may not have used any topical or systemic retinoids in the past 6 months.
• Women who are pregnant or nursing may not participate.
• If you have a history of non-melanoma skin cancer on the face in the past 5 years, you may not participate.
• If you have any history of malignant melanoma you may not participate.
• If you have any other skin condition or facial hair that will interfere with the study evaluations, you may not participate.
• If you have a known sensitivity to any of the ingredients in the study cream or Dove products, you may not participate.
• If you are currently on special daily skin care regimens that include cleansing with Dove, Olay, Aveeno or Cetaphil liquid facial cleansers and using facial moisturizers more than twice a day you may not participate.