Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2010 by Medical University of South Carolina.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Information provided by:
Medical University of South Carolina
ClinicalTrials.gov Identifier:
NCT00438685
First received: February 21, 2007
Last updated: July 30, 2010
Last verified: July 2010

February 21, 2007
July 30, 2010
October 2004
August 2007   (final data collection date for primary outcome measure)
  • Urine Drug Screen at 4 weeks, 8 weeks, 12 weeks, 24 weeks
  • Score on Depression/Anxiety Scale (RCADS) at 4 weeks, 8 weeks, 12 weeks, 24 weeks
Same as current
Complete list of historical versions of study NCT00438685 on ClinicalTrials.gov Archive Site
  • Measured at Intake, 3 Months, and 6 Months
  • Global assessment of symptoms
  • Parenting
  • School
  • Behavioral
  • Family relationship/communication/problem solving
  • Consumer satisfaction
  • Daily Drug/Alcohol use
Same as current
Not Provided
Not Provided
 
Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders
Development of Outpatient MST for Dually Diagnosed Youth

Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society. Moreover, rates of psychiatric comorbidity among substance abusing youth range from 25% up to 82%, and youths with a dual diagnosis have worse outcomes and are more than twice as costly to treat than their counterparts with no comorbidity. This project was a pilot test of a new treatment, OPTION-A, which was adapted from Multisystemic Therapist (MST) and other evidence-based interventions to specifically treat youth presenting for outpatient treatment of comorbid substance use and internalizing disorders. The project was a randomized controlled pilot trial comparing the experimental treatment to usual services in the community.

Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society. Moreover, rates of psychiatric comorbidity among substance abusing youth are high and youths with a dual diagnosis are more costly to treat. At the time of this study, however, no outpatient treatments had been tested specifically for treating youth with co-occurring substance use disorders and mental health diagnoses. The current project aimed to adapt and evaluate Multisystemic Therapy (MST), a well validated treatment for chronic behavioral problems or serious emotional disturbance in adolescents, to treat dually diagnosed youth using an outpatient model of service delivery.

A pilot trial was conducted with 40 dually diagnosed youth randomly assigned to treatment conditions, with 20 receiving the experimental treatment (OPTION-A) and 20 receiving usual outpatient services. Specific aims were:

Specific Aim 1: The primary aim of the present research was to adapt and test OPTION-A for use in outpatient settings to treat youth diagnosed with a substance use disorder and comorbid internalizing disorder. We hypothesized that youth receiving OPTION-A would exhibit significantly less drug use (e.g., youth self-reports and urine screens) than control youth who received usual services, and that youth receiving OPTION-A would exhibit significant improvement on indices of mental health (e.g., combined youth and caregiver reports on diagnostic interviews and youth, caregiver, and teacher reports of internalizing symptoms) compared to control youth Specific Aim 2: In addition to improved symptomatology, the current research aimed to test the effectiveness of OPTION-A to improve youth functioning in other domains pertinent to successful adolescent development. We hypothesized that youth receiving OPTION-A would evidence improved behavioral (e.g., youth, caregiver, and teacher reports of externalizing), school (e.g., school attendance), and family functioning (e.g., youth and caregiver reports of family adaptability and cohesion) compared to control youth who received usual services.

Specific Aim 3: The final aim of the proposed research was to provide services that are more acceptable to consumers than are usual services provided in the community. We hypothesized that youth and families receiving OPTION-A would experience significantly greater consumer satisfaction than control youth and families who received usual services.

Interventional
Phase 1
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Factorial Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
  • Substance-Related Disorders
  • Depressive Disorder
  • Anxiety Disorder
  • Behavioral: Outpatient MST/OPTION-A
  • Behavioral: Usual Services
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
40
September 2010
August 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Presentation for outpatient treatment
  • 12 to 17 years of age
  • Youth residing with at least one adult caregiver who serves as a parent figure
  • Substance Abuse or Dependence Disorder
  • Axis I Internalizing Disorder (Mood Disorder or Anxiety Disorder), based on the Diagnostic Interview Schedule for Children (DISC-IV; Shaffer, Fisher, Lucas, Dulcan, & Schwab-Stone, 2000)

Exclusion Criteria:

  • Pervasive Developmental Disorder
  • Psychotic Disorder
  • Severe or profound mental retardation (IQ of 45 or below)
  • Families previously receiving Multisystemic Therapy
Both
12 Years to 17 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00438685
1R21DA017118 01, R21DA017118
Not Provided
Ashli J. Sheidow, MUSC
Medical University of South Carolina
National Institute on Drug Abuse (NIDA)
Principal Investigator: Ashli J Sheidow, PhD Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, Family Services Research Center
Study Chair: Scott W Henggeler, PhD Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, Family Services Research Center
Medical University of South Carolina
July 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP