Frequency of ICAM-1 Polymorphisms in Obese Subjects - Tabular View

Tracking Information

First Received Date ^ICMJE

February 16, 2007

Last Updated Date

February 16, 2007

Start Date ^ICMJE

January 2005

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

No Changes Posted

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Frequency of ICAM-1 Polymorphisms in Obese Subjects

Official Title ^ICMJE

Study of the Association Between ICAM-1 Polymorphisms and Severe Obesity

Brief Summary

The genetic contribution to the development of obesity is now well recognized. However obesity is a polygenic disease and thus many genes are likely to be involved. This study aims to investigate the possible association between specific variants of the gene coding for the Intercellular Adhesion Molecule-1 (ICAM-1)and the development of severe obesity in an Italian population

Detailed Description

Severely obese subjects referred to our institution will be evaluated. For the aim of the study, a venous blood sample will be obtained from these subjects and from a group of normal weight volunteers. Genomic DNA will be extracted from the blood samples and analysed by standard molecular biology techniques.The allelic and genotype frequencies of the two ICAM-1 variants will be calculated in the obese and control groups. The statistical significance of possible differences will be determined

Study Phase

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal, Time Perspective: Prospective

Condition ^ICMJE

Obesity

Intervention ^ICMJE

Study Arms / Comparison Groups

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Enrollment ^ICMJE

200

Completion Date

July 2006

Primary Completion Date

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Obesity

Exclusion Criteria:

Associated inflammatory diseases

Gender

Both

Ages

18 Years to 60 Years

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

Administrative Information

NCT ID ^ICMJE

NCT00436488

Responsible Party

Study ID Numbers ^ICMJE

12C501

Study Sponsor ^ICMJE

Istituto Auxologico Italiano

Collaborators ^ICMJE

Investigators ^ICMJE

Principal Investigator:

Anna Maria Di Blasio, MD

Istituto Auxologico Italiano

Information Provided By

Istituto Auxologico Italiano

Verification Date

February 2007

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP