The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis (INVEST-PD)

This study has been completed.
Sponsor:
Information provided by:
Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier:
NCT00433264
First received: February 7, 2007
Last updated: March 4, 2009
Last verified: March 2009

February 7, 2007
March 4, 2009
February 2007
December 2008   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00433264 on ClinicalTrials.gov Archive Site
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The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis
The Interrelation of the Vasculature, Endothelium, Bone Metabolism and Uremic Toxins in Peritoneal Dialysis

Despite major advances in the treatment of chronic kidney disease, the age and sex matched mortality far exceeds that of the normal population. As in the normal population, the majority of deaths are related to cardiovascular disease. Mounting data point to the lethal synergy between chronic kidney disease and cardiovascular disease. This relation is present from early stages of chronic kidney disease on.

Several uremic toxins have been demonstrated to play an important role in kidney disease related endothelial dysfunction. In peritoneal dialysis patients, data on the relation between uremic toxins, endothelial dysfunction and microparticles are lacking.

The investigators hypothesize that endothelial dysfunction and uremic toxins are interrelated in peritoneal dialysis patients

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Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

serum, plasma, DNA

Non-Probability Sample

Tertiary referral center university hospital

Chronic Kidney Disease
Procedure: peritoneal dialysis
individualised
Other Name: individualised
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
62
December 2008
December 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • age > 18
  • Maintenance peritoneal dialysis

Exclusion Criteria:

  • No informed consent
  • Peritonitis
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Belgium
 
NCT00433264
ML3645
Yes
Pieter Evenepoel, University Hospitals Leuven
Universitaire Ziekenhuizen Leuven
Not Provided
Principal Investigator: Bjorn Meijers, MD UZ Leuven
Principal Investigator: Kathleen Claes, MD UZ Leuven
Study Director: Pieter Evenepoel, MD, PhD UZ Leuven
Universitaire Ziekenhuizen Leuven
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP