Brain Power: Resistance Training and Cognitive Function

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2011 by University of British Columbia.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Michael Smith Foundation for Health Research
Information provided by (Responsible Party):
University of British Columbia
ClinicalTrials.gov Identifier:
NCT00426881
First received: January 23, 2007
Last updated: September 28, 2011
Last verified: September 2011

January 23, 2007
September 28, 2011
January 2007
June 2012   (final data collection date for primary outcome measure)
Cognitive Performance of Executive Function [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Cognitive Performance of Executive Function
Complete list of historical versions of study NCT00426881 on ClinicalTrials.gov Archive Site
Functional MRI and physiological falls risk [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Functional MRI and physiological falls risk
Not Provided
Not Provided
 
Brain Power: Resistance Training and Cognitive Function
The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65-75 Years Old: A 12-Month RCT

Primary Objectives:

1. To ascertain whether a 12-month, twice-weekly or once-weekly resistance training (RT) program will significantly improve executive function in community-dwelling women aged 65 to 75 years old compared with a 12-month, twice-weekly stretch and relax (S & R) program (shame exercise). We will assess executive function by standard neuropsychological tests.

Secondary Objectives:

  1. To describe the neural mechanisms that underpin the observed changes in executive function associated with a 12-month, twice-weekly or once-weekly RT training (by using functional magnetic resonance imaging (fMRI)).
  2. To investigate whether RT-induced changes in executive function are independently associated with changes in physiological fall risk profile.
  3. To investigate the dose response of RT (resistance training) on bone health as measured by dual energy x-ray and peripheral quantitative computed tomography.
  4. To conduct a one-year follow-up after the formal cessation of the resistance training programs to determine the persisting effect of resistance training on cognitive performance, cortical plasticity, physiological falls risk, and bone health.

Primary Research Question: Does resistance training (RT) significantly improve cognitive function, specifically executive function in older women with a Mini-Mental State Examination (MMSE) score equal to or greater than 24 (i.e., cognitively intact) compared with a stretch & relax (S & R; control) program?

Secondary Research Questions:

  1. Are changes in cortical activation associated with RT-induced changes in executive function?
  2. Are RT-induced improvements in executive function associated with lowered physiological fall risk?
  3. Is there a dose-response on bone health with RT (resistance training)?

RESEARCH PLAN:

Study Design: A 12-month, single-blinded, randomized controlled trial. Participants: 155 cognitively-intact (i.e., MMSE score > 24), right-handed, sedentary community-dwelling women, aged 65 to 75 years.

Measurement: Measurements will take place at baseline, six month, and trial completion. Standard neuropsychological testing and physiological fall risk assessment will occur at all three measurement sessions. A subset of the participants (20 from each experimental group) will undergo fMRI assessment at baseline and trial completion only. Exercise Classes: Participants will be randomized to a 12-month, twice-weekly or once-weekly RT program or stretch & relax program (control). All exercises will be offered at a Vancouver YMCA with whom we have partnered previously. Sample Size Justification: The sample size of 50 per experimental group (i.e., N = 155) is based on the primary end point of this study, cognitive performance of executive function. SUMMARY: Falls are a major challenge for the senior population. To date, no intervention has significantly reduced falls among those with cognitive impairment. Our immediate primary goal is to test whether RT can improve cognitive performance of executive function; impaired executive function are associated with injurious falls. If this proposed exercise trial proves successful, the RT intervention will be trialed in the future in a larger study powered for falls.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Prevention
Healthy
  • Behavioral: Exercise Training
    Twice weekly resistance training for 52 weeks.
  • Behavioral: Exercise training
    Once weekly resistance training for 52 weeks.
  • Behavioral: Exercise training
    Twice weekly resistance training for 52 weeks.
  • Experimental: 1
    Twice weekly resistance training for 52 weeks.
    Intervention: Behavioral: Exercise Training
  • Experimental: 2
    Once weekly resistance training for 52 weeks.
    Intervention: Behavioral: Exercise training
  • Experimental: 3
    Twice weekly balance and tone training for 52 weeks.
    Intervention: Behavioral: Exercise training

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
155
June 2012
June 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Sedentary (less than twice weekly exercising) women aged 65-75 years old without conditions restricting them from exercising.
Female
65 Years to 75 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Canada
 
NCT00426881
H06-03216, ORSIL 06-1737, ORSIL 05-6933
No
University of British Columbia
University of British Columbia
Michael Smith Foundation for Health Research
Principal Investigator: Teresa Liu-Ambrose, Ph.D University of British Columbia
University of British Columbia
September 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP