Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System - Tabular View

Tracking Information

First Received Date ^ICMJE

January 19, 2007

Last Updated Date

February 4, 2009

Start Date ^ICMJE

November 2006

Primary Completion Date

April 2007 (final data collection date for primary outcome measure)

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00424957 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

Official Title ^ICMJE

Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Brief Summary

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Detailed Description

Study Phase

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Case Control, Cross-Sectional

Condition ^ICMJE

Cirrhosis
Hepatic Encephalopathy

Intervention ^ICMJE

Study Arms / Comparison Groups

Publications *

Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. Review.

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Estimated Enrollment ^ICMJE

Completion Date

October 2008

Primary Completion Date

April 2007 (final data collection date for primary outcome measure)

Eligibility Criteria ^ICMJE

Inclusion Criteria:

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
6 healthy subjects age and sex matched

Exclusion Criteria:

Neurological and/or psychiatric condition,
Non-treated diabetes,
Pregnancy/breast-feeding

Gender

Both

Ages

45 Years to 65 Years

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

Denmark

Administrative Information

NCT ID ^ICMJE

NCT00424957

Responsible Party

Peter Iversen, PET Center, Aarhus University Hospital

Study ID Numbers ^ICMJE

20060120

Study Sponsor ^ICMJE

University of Aarhus

Collaborators ^ICMJE

Investigators ^ICMJE

Study Chair:

Susanne Keiding, MD

PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital

Information Provided By

University of Aarhus

Verification Date

February 2009

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP