• Measurement visits will be conducted at the PACE office. The specific activities to be conducted at the baseline, 6 and 12 week assessment visits are listed below.
• Physiological Measures
• Height and weight
• Waist & hip, circumference
• Blood pressure and pulse
• Physical activity level measured by wearing a monitor around the waist for 3 days (at baseline and 12 weeks only)
• Interview/Survey Measures
• Self report depressive symptoms
• Self-report of moderate and vigorous physical activity for seven days
• Self-report of TV viewing and recreational computer use for seven days
• Self-report on readiness to make changes in physical activity and mood management behaviors
• Personal assessment of factors related to behavior change including: self-efficacy, social support, barriers to change, and use of behavior change skills, and the environment

Researchers at the University of California at San Diego (UCSD) are conducting a 12-week study to test the PACEPRO program. This program is designed to reduce depression by providing:

Lexapro, an antidepressant medicine…Learn More Physical activity information and pedometer Mood management skills and a Mood Mastery Guide Personalized support from a Family Nurse Practitioner

• Drug: Lexapro, an antidepressant medicine
• Behavioral: Physical Activity
• Behavioral: Mood Management Skills
• Behavioral: Personalized support from a Family Nurse Practitioner

Inclusion Criteria:

• Have been diagnosed with mild to moderate depression
• Are willing to take the antidepressant Lexapro
• Can access and use Email and the Internet
• Are willing and able to be physically active
• Access to a primary care physician

Exclusion Criteria:

Subjects will be excluded from participation for the following reasons:

• Pregnancy or breastfeeding
• Narrow angle glaucoma
• Any uncontrolled medical condition or any medical condition which would represent a contraindication to Escitalopram Oxalate Lexapro® pharmacotherapy. Any concomitant non-psychotropic medications that the physician determines are a contraindication to Escitalopram Oxalate Lexapro® pharmacotherapy Bipolar disorder, or any psychotic or organic mental disorder or dementia
• History of intolerance or allergy to Lexapro, or of prior failed treatment for depression with Lexapro
• Current substance abuse or dependency
• Current active suicidal ideation
• Current use of herbal psychoactive treatments such as St. John’s Wort
• Concurrent psychotropic medication is not permitted for 2 weeks prior to randomization (4 weeks in the case of fluoxetine) or at any point after
• Receipt of formal psychotherapy concurrently
• Inability, in the investigator’s opinion, to comply with study procedures or assessments
• Inability to exercise