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Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers

This study has been completed.
Sponsor:
Information provided by:
University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier:
NCT00416052
First received: December 26, 2006
Last updated: May 18, 2011
Last verified: May 2011

December 26, 2006
May 18, 2011
March 2004
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Complete list of historical versions of study NCT00416052 on ClinicalTrials.gov Archive Site
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Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers
Relation Between Bone Mineral Density and the Regulation of Mineral Metabolism in Renal Stone Formers

Accumulating evidence indicated that renal calcium stone formers often exhibit a low bone density. Therefore we want to test the hypothesis, that the mineral (calcium) metabolism is differently regulated in calcium stone formers with low as opposed to high bone density.

There is epidemiological evidence associating renal calcium stones and decreased bone mineral density (BMD). The decreased BMD in calcium stone formers is linked to hypercalciuria and both subtypes, fasting as well as absorptive hypercalciuria are associated with a diminished BMD. Higher 1,25-vitamin D plasma concentrations and lower PTH levels are encountered under free-choice diet conditions in patients diagnosed with absorptive and fasting hypercalciuria when compared to normocalciuric stone formers. Reports studying the BMD of stone formers and its link with mineral metabolism variables and urinary calcium excretion under different calcium intakes are rare.

We hypothesize now that PTH and 1,25-vitamin D change differently when calcium stone formers with high, intermediate and low BMD are challenged by a low calcium diet.

Observational
Observational Model: Case-Only
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Non-Probability Sample

Recurrent renal calcium stone formers

Calcium Nephrolithiasis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
90
June 2006
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Inclusion Criteria:

  • passage of at least one calcium containing kidney stone

Exclusion Criteria:

  • established cause of calcium stone formation (sarcoidosis, primary hyperparathyroidism etc.)
  • creatinine clearance < 60 ml/min
  • urinary tract infection
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Switzerland
 
NCT00416052
BE001
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Andreas Pasch, Department of Nephrology and Hypertension, Inselspital, University Hospital Bern
University Hospital Inselspital, Berne
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Study Director: Felix J Frey, MD University of Bern
University Hospital Inselspital, Berne
May 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP