Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

This study has been terminated.
Sponsor:
Information provided by:
Grünenthal GmbH
ClinicalTrials.gov Identifier:
NCT00388219
First received: October 13, 2006
Last updated: July 5, 2007
Last verified: July 2007

October 13, 2006
July 5, 2007
October 2006
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00388219 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Single Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations
Single Dose Bioequivalence Trial Comparing a New Analgesic Transdermal Patch Formulation to an Analgesic Reference Patch

The purpose of this study is to determine whether Transtec (R) PRO 70 µg/h and a new buprenorphine patch formulation lead to same plasma levels of buprenorphine after single dose application

Main: to demonstrate the bioequivalence of the new buprenorphine transdermal patch T2rev formulation containing 13 mg buprenorphine (Test) as compared to Transtec (R) PRO 70 µg/h patch transdermal patch containing 40 mg buprenorphine as reference (Reference) after single patch application. Pharmacokinetic target parameters are AUC, AUCo-t, and Cmax.

Further: To assess the safety, tolerability, skin tolerability and adhesiveness of the patch applications

Interventional
Phase 1
Allocation: Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Healthy
Drug: Transtec (R) PRO (buprenorphine)
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
24
November 2006
Not Provided

Inclusion Criteria:

  • Male Cucasian subjects, aged 18-55 years
  • BMI between 18 and 30 kg/m2 inclusive, with a lower limit of body weight of 50 kg
  • Subjects must be in good health as determined by medical history, physical examination, 12-lead electrocardiogram, vital signs and clinical laboratory parameters
  • Subjects giving written informed consent to participate within this trial

Exclusion Criteria:

  • Resting pulse <= 45 or >= 100 beats/min
  • Resting blood pressure: systolic blood pressure <= 90 and >= 160 mmHg, diastolic blood pressure <= 40 and >= 100 mmHG
  • History or presence of orthostatic hypotension
  • Positive test of HIV type 1/2 antibodies, HBs antigen, HBc antibodies, HCV antibodies
  • Participation in another clinical trial in the last 30 days before starting this trial (i. e., first administration of IMP)
  • Positive drug of abuse screening
  • Diseases or condition known to interfere with the absorption, distribution, metabolism or excretion of drugs
  • Marked repolarisation abnormality (e.g., suspicious or definite congenital long QT syndrome with QT/QTc>500msec or prolonged QTc, i.e.>450msec) or co- medication that is known to influence cardiac repolarisation substantially
  • Bronchial asthma
  • Definite or suspected history of drug allergy or hypersensitivity
  • Subjects who have received any prescribed and non-prescribed systemic or topical medication like analgesics, NSAIDs (except standard dose of a NSAID once a week for the treatment of headache), hypnotics, sedatives, narcotics, neuroleptics or other medications that may lower the seizure threshold, MAO- inhibitors, serotonin-reuptake-inhibitors, tricyclic antidepressants, other centrally acting substances and substances which are known to interact with the drug metabolizing enzymes (e.g., inhibitors or inducers of CYP3A4 or CYP2D6) four weeks prior to the start of the trial (i.e. first administration of IMP). Each case has to be decided upon individually by the investigator after consultation with the Sponsor
  • Evidence of alcohol or drug abuse
  • Not able to abstain from consumption of:Caffeine containing beverages or food (tea, coffee, cola, chocolate, etc.) Quinine containing beverages or food (bitter lemon, tonic water) Grapefruit juice (sweet, sour) Poppy seeds containing beverages or food
  • Blood loss (> 100 ml) due to e.g. blood donation within 3 months before starting this trial (i.e., first administration of IMP)
  • History of seizures or at risk (i.e. head trauma, epilepsy in family anamnesis, unclear loss of consciousness)
  • Known or suspected of not beeing able to comply with the trial protocol
  • Not able to communicate meaningfully with the investigator and statt
  • Smoking of > 10 cigarettes/day or equivalent

Trial specific exclusion criteria:

  • Subjects not able to abstain from strenuous exercise during the whole course of the trial
  • Abnormality (e.g. scar, tattoo) or unhealthy skin at application site according to examination by the investigator
  • Existing chronic skin disease or history of skin disease at the application site within the last 4 weeks
  • Presence of one of the contraindications as detailed in the current Summary of Product Characteristics (SmPC)
Male
18 Years to 55 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT00388219
964711
Not Provided
Not Provided
Grünenthal GmbH
Not Provided
Principal Investigator: Dr. Baumann-Noss, MD IKP Mannheim
Grünenthal GmbH
July 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP