"Nephrology Research BioBank"

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2012 by University of Michigan
Sponsor:
Information provided by (Responsible Party):
Matthias Kretzler, University of Michigan
ClinicalTrials.gov Identifier:
NCT00381121
First received: September 26, 2006
Last updated: November 13, 2012
Last verified: November 2012

September 26, 2006
November 13, 2012
September 2006
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00381121 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
"Nephrology Research BioBank"
Michigan Nephrology Research BioBank for Molecular Analysis of Renal Disease "Nephrology Research BioBank"

The purpose of the study is to create a Nephrology Tissue Biobank enabling the study of kidney disease from the perspectives of epidemiology, genetics and molecular biology.

Each year chronic kidney disease (CKD) claims the lives of millions of people worldwide. Costs for patient care are in excess of 2.4 billion dollars in the US alone. At the moment most kidney diseases are of unknown etiology, are classified according to a microscopic description of the kidney tissue obtained on biopsy and are treated with non-specific therapies.

Each kidney contains millions of filter units called nephrons. The nephron consists of a glomerulus and a tubule. The glomerulus filters the blood of waste products, while retaining larger molecules that are required for the body to function properly. The filtered fluid then passes through the tubule, where salts, acids and water are regulated to keep the body in a normal metabolic state. After the filtered fluid passes through the tubule it is collected in the bladder as urine. Diseases, which affect the glomeruli or tubules result in kidney damage. Once kidney function is lost it is generally not recoverable and the only option for a patient's survival is dialysis or transplantation.

The purpose of this study is to provide a platform, which will enable researchers with different areas of expertise, to investigate the molecular markers and pathways of kidney disease and its progression. Our goal is to increase our understanding of kidney health issues and to develop new prevention and treatment strategies which will be shared with the medical community and the public.

Study description:

Individuals seen in the nephrology clinic at the University of Michigan will be eligible to enroll in this study. Their clinical data will be recorded, blood and urine samples will be collected and if a biopsy is performed as a part of their standard medical care then a small sample will be reserved for use in the study after all pathological evaluations required for patient care are completed. Biological samples will be available for biochemical, molecular biological and genetic testing and for correlation of these parameters to the individuals clinical data in future studies.

Significance:

Advances in the understanding of kidney disease may 1) provide methods of early detection of disease, 2) identify molecular markers that will help physician prescribe the most appropriate and beneficial treatments, 3) identify targets for the development of new treatments, and 4) decrease the enormous cost of caring for individuals with CKD.

Aim:

  1. Create a biobank enabling the study of kidney disease from the perspectives of epidemiology, genetics and molecular biology.
  2. Create a resource for the study of kidney disease, which will enable the researchers at the University of Michigan to work collaboratively toward the elucidation of the molecular pathways, which cause kidney disease.
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Tissue, blood, urine

Non-Probability Sample

Renal disease patients undergoing diagnostic workup

Chronic Kidney Disease
Procedure: Kidney and/or Pancreas biopsy
Clinical care biopsies surplus tissue used for study
Kidney disease cohort
Intervention: Procedure: Kidney and/or Pancreas biopsy
Schmid H, Henger A, Kretzler M. Molecular approaches to chronic kidney disease. Curr Opin Nephrol Hypertens. 2006 Mar;15(2):123-9. Review.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
420
August 2056
Not Provided

Inclusion Criteria:

  • Men, women and children undergoing kidney and/or pancreas biopsy at the University of Michigan
Both
Not Provided
No
Contact: Chrysta Lienczewsky 734-764-2924 boridley@med.umich.edu
United States
 
NCT00381121
HUM 4729
No
Matthias Kretzler, University of Michigan
University of Michigan
Not Provided
Principal Investigator: Matthias Kretzler,, MD University of Michigan
University of Michigan
November 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP