Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy

This study has been completed.
Sponsor:
Information provided by:
NEMA Research, Inc.
ClinicalTrials.gov Identifier:
NCT00380965
First received: September 25, 2006
Last updated: February 14, 2008
Last verified: February 2008

September 25, 2006
February 14, 2008
October 2006
October 2007   (final data collection date for primary outcome measure)
The Average Pain Score at target site.
Same as current
Complete list of historical versions of study NCT00380965 on ClinicalTrials.gov Archive Site
  • The Worst Pain Score at target site.
  • The Pain at Night Score at target site.
  • Quality of Life measures.
  • Patient satisfaction with treatment.
  • Safety will be assessed through the collection of AEs and vital signs.
Same as current
Not Provided
Not Provided
 
Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy
A Multicenter Trial Evaluating the Safety and Efficacy of Cesamet™ for the Symptomatic Treatment of Chemotherapy-Induced Neuropathic Pain in Patients With Cancer

This study was designed to evaluate the safety and efficacy of Cesamet™ in controlling pain in subjects experiencing pain due to chemotherapy-induced neuropathic pain in patients with cancer.

To determine the safety and efficacy of Cesamet™ in the symptomatic treatment of chemotherapy-induced neuropathic pain.

This is a phase IV, multicenter, open label of Cesamet™ at 1 mg daily progressing to 2mg BID in subjects with chemotherapy-induced neuropathic pain. This study has two phases: A pretreatment phase and a treatment phase.

Interventional
Phase 4
Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Peripheral Neuropathy
  • Antineoplastic Combined Chemotherapy Protocols
Drug: Cesamet™ (nabilone)
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
23
October 2007
October 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients diagnosed with chemotherapy-induced neuropathic pain.
  • Chronic daily pain present for at least 2 months.
  • On stable analgesic regimen for one month.
  • Baseline pain score greater than 40mm on a VAS.

Exclusion Criteria:

  • Hypersensitivity to compounds in study drug or similar drugs
  • Pregnant or lactating females
  • Drug or alcohol abuse
  • Unstable medical condition
Both
18 Years to 75 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00380965
CB1 Study 003
Not Provided
Not Provided
NEMA Research, Inc.
Not Provided
Principal Investigator: Joseph V Pergolizzi, MD NEMA Research, Inc.
Study Director: Charlotte A Richmond, PhD NEMA Research, Inc.
NEMA Research, Inc.
February 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP