| August 24, 2006 |
| May 7, 2009 |
| January 2007 |
| January 2009 (final data collection date for primary outcome measure) |
| Peripheral blood will be collected from adults ages 18-55. These samples will then be used for PCR analysis and T cell cloning. [ Time Frame: 2 Years ] [ Designated as safety issue: No ] |
| Peripheral blood will be collected from adults ages 18-55. These samples will then be used for PCR analysis and T cell cloning. |
| Complete list of historical versions of study NCT00368784 on ClinicalTrials.gov Archive Site |
| characterizing the T cell repertoire of individuals with immune mediated skin disease (e.g. psoriasis and mycosis fungoides). [ Time Frame: 2 Years ] [ Designated as safety issue: No ] |
| characterizing the T cell repertoire of individuals with immune mediated skin disease (e.g. psoriasis and mycosis fungoides). |
| |
| T Cell Repertoire Analysis of Immune Mediated Skin Diseases |
| T Cell Repertoire Analysis of Immune Mediated Skin Diseases |
This study is designed to identify the cells of the immune system that cause skin disease such as psoriasis and mycosis fungoides. Blood samples from many patients will be compared in hopes of finding common cells and molecules responsible for skin diseases. Results of this study will increase our knowledge about immune mediated skin disease. |
The aim of the study is to characterized the T cell repertoire of individuals with immune mediated skin disease (e.g. psoriasis and mycosis fungoides). Peripheral blood with be collected from volunteers with psoriasis, mycosis fungoides and age matched controls. Fifteen tablespoons of blood will be collected prior to the initiation of treatment and again after the patient shows a clinical response to treatment. The time between blood draws will be no less than 3 months. There will be no more than two blood draws per patient. Blood samples will be used to determine the patient's HLA haplotype via PCR and DNA sequencing. After the patient's haplotype has been established the activated T cell repertoire will be analyzed for clonal expansions. Clonal expansions in the T cell repertoire will be determined by immunoscope analysis, which is a PCR based technique. |
| Phase III |
| Observational |
| Case Control, Prospective |
- Psoriasis
- Mycosis Fungoides
|
| |
- Have an immune mediated skin disease, such as psoriasis or mycosis fungoides
- Age-Matched Controls
|
| |
| |
| Recruiting |
| 50 |
| August 2009 |
| January 2009 (final data collection date for primary outcome measure) |
Inclusion Criteria:
- Have an immune mediated skin disease, such as psoriasis or mycosis fungoides
- Are not taking immunosuppressive medications, which may interfere with T cell analysis.
Exclusion Criteria:
- are taking immunosuppressive medications, which may interfere with T cell analysis
|
| Both |
| 18 Years to 55 Years |
| Yes |
|
|
| United States |
| |
| NCT00368784 |
| Fu-Tong Liu, MD, University of California Davis |
| 200513098-1 |
| University of California, Davis |
|
| Principal Investigator: |
Fu-Tong Liu, M.D. |
University of California, Davis |
|
|
| University of California, Davis |
| May 2009 |
