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Influence of Physical Training on Mitochondrial Function in Type 2 Diabetic Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by Odense University Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Odense University Hospital
ClinicalTrials.gov Identifier:
NCT00365495
First received: August 15, 2006
Last updated: April 3, 2007
Last verified: April 2007

August 15, 2006
April 3, 2007
August 2006
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Mitochondrial respiratory measurements. The investigations are carried out by two rounds - one before Christmas and one after.
Same as current
Complete list of historical versions of study NCT00365495 on ClinicalTrials.gov Archive Site
  • VO2max
  • Lipid oxidation
  • muscle fiber type composition
  • muscle oxidative enzymes
  • mitochondrial-specific proteins (UCP3)
  • mitochondrial production of free oxygen radicals
Same as current
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Influence of Physical Training on Mitochondrial Function in Type 2 Diabetic Patients
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Physical activity as treatment for patients with type 2 diabetes (T2D). Treatment of T2D is often done by medication, changing the diet and increased physical activity. It is well established that physical training has a positive effect on the pathology of T2D such as increased insulin sensitivity and reduced fasting plasma glucose (7) and blood lipids (15). It is also well known that in healthy subjects endurance training increases mitochondrial density, lipid oxidation during submaximal exercise, and results in a number of qualitative changes in the control of OXPHOS (24). However, the effect of physical training on the mitochondrial function in skeletal muscle of patients with T2D has not been investigated.

The purpose of this project is to investigate the effect of physical training on the mitochondrial respiratory function in muscles of patients with T2D. Skeletal muscle biopsies will be taken before and after 10 weeks of physical training in patients with T2D and matched control subjects. Mitochondria will be isolated from the muscle biopsies, and respiratory function, free radical production and UCP3 will be determined. Furthermore, measures of maximal oxygen consumption (VO2max), heart rate and capillary lactate concentrations and carbohydrate and lipid oxidation will be determined partly to verify an increased aerobic capacity and partly to investigate the changes in these factors in T2D patients.

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Interventional
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Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Treatment
Type 2 Diabetes
Procedure: Physical training (aerobic training)
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
30
June 2007
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Inclusion Criteria:

  • Male,
  • BMI above 26,
  • Age between 40 and 65,
  • Living a sedentary lifestyle

Exclusion Criteria:

  • Women
  • BMI under 26
  • Age under 40 and over 65
  • Trained subjects Control subjects: relatives to type 2 diabetic patients, T2D trial subjects
Male
40 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00365495
022
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Odense University Hospital
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Principal Investigator: Martin Mogensen, PhD student University of Southern Denmark
Odense University Hospital
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP