Full Text View
Tabular View
No Study Results Posted
Related Studies
Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP)
This study is currently recruiting participants.
Study NCT00356993   Information provided by Centre for Addiction and Mental Health
First Received: July 25, 2006   Last Updated: February 9, 2009   History of Changes

July 25, 2006
February 9, 2009
October 2005
March 2009   (final data collection date for primary outcome measure)
  • Smoking cessation outcome measures [ Time Frame: 6months post quit date ] [ Designated as safety issue: No ]
  • Health care utilization measures [ Time Frame: 3, 6 months followup ] [ Designated as safety issue: No ]
  • Smoker and provider satisfaction [ Time Frame: 3 months and 6 month followup if no longer smoking ] [ Designated as safety issue: No ]
  • Smoking cessation outcome measures
  • Health care utilization measures
  • Smoker and provider satisfaction
Complete list of historical versions of study NCT00356993 on ClinicalTrials.gov Archive Site
 
 
 
Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP)
The STOP (Stop Smoking Therapy for Ontario Patients) Study: The Effectiveness of Nicotine Replacement Therapy in Ontario Smokers.

20% of Ontarians smoke. There was a decline in smoking prevalence from 1995 but it has remained unchanged since 2002. This rate of smoking cessation has not kept up with the rest of Canada. A new strategy is necessary to increase the number of smokers making quit attempts and to increase the odds of quitting long term.The goal of this study is to evaluate the methods and effectiveness of providing nicotine replacement (NRT) to Ontario smokers. The study will develop an evidence-based protocol for providing NRT, provide faculty development on combining pharmacotherapy with behavioural interventions and will provide an evaluation framework to inform future coverage models.

According to the US Surgeon General's Report (1988), there are immediate, intermediate and long-term benefits to health from quitting smoking. For example, there is a 50% reduction in coronary heart disease risk in 12 months and the risk of a stroke is reduced to that of a nonsmoker 5-15 years after quitting. (US Surgeon General's Report, 1990, p.vi). In a systematic assessment of the value of clinical preventive services recommended by the US Preventive Services Task Force, smoking cessation treatment for adults was one of the highest-ranked services in terms of its cost effectiveness and its potential to reduce the burden of disease. Most smoking cessation interventions cost less per year of life saved than most widely accepted medical practices. For example, cost-effectiveness analysis of the implementation of the Agency for Healthcare Research and Quality (AHRQ) guidelines show costs of $4,113 per life-year saved, in 2001 prices compared to annual mammography for women aged 40 to 49 years, which costs $71,751 in 2001 prices, and hypertension screening for men aged 40 years, which costs $27,117 in 2001 prices. Therefore, smoking cessation services have been referred to as the "gold standard" for comparing the cost effectiveness of other healthcare interventions. Although some studies have shown high costs from increased healthcare utilization in the first year after quitting smoking due to illness (Martinson, 2003), most studies demonstrate that smokers who quit eventually have significantly lower healthcare utilization than continuing smokers (Fishman, 2003; Warner, 2003) Thus, for healthcare organizations such as the Ontario Health Insurance Plan, implementing smoking cessation services will likely result in a relatively quick return on investment. Both the intensity and duration of behavioural interventions are associated with sustained remission in smoking. The addition of pharmacotherapy doubles the odds of quitting successfully. However, many smokers face barriers in accessing pharmacotherapy. The provision of free pharmacotherapy has the potential to help a substantial number of smokers to quit. A study by Curry et al, 1998, evaluated smokers who were willing to sign up for a cessation-support program under various degrees of coverage for either the program or nicotine replacement therapy (NRT). 10% of Smokers with full coverage were likely to attempt to quit as opposed to 2.5% with partial coverage. Therefore, the USHHS guidelines call for the coverage of these medications. Research has shown that coverage for tobacco dependence treatments can enhance not only the rate of quit attempts but also long-term abstinence for smokers (Levy & Friend, 2002; Schauffler, McMenamin, Olson, Boyce-Smith, Rideout, & Kamil, 2001). On average, the odds ratio of quitting at one year was 1.6 for those given free NRT. Therefore, some insurers, both public and private, reimburse patients for stop smoking medications. However, a study by Boyle et al 2002, found that simply including the medication in an insurance plan did not increase quit rates or utilization of medications. Adequate precautions must be taken to ensure that free pharmacotherapy is distributed in conjunction with behavioural interventions to be successful and to be used by those smokers most likely to benefit from pharmacotherapy.Pharmacotherapy can be very expensive if provided to all smokers. However, not all smokers want to quit or require medications to quit (McDonald, 2003). Most smokers use about 2-3 weeks of pharmacotherapy when not combined with behavioural interventions (Pierce, 2002). About 0.05% of smokers looking to quit will seek specialized care. Moreover, if we assume that 70% of current tobacco users (Approximately 1.6 million) in Ontario will try to quit in a given year and that 10% ( i.e. 169,000) of these individuals would qualify for and seek reimbursement for 10 weeks of therapy at $30/week, then the total estimated cost will be about $50 million! This is clearly not fundable and therefore a comprehensive strategy combined with some rational use of pharmacotherapy is necessary.Hypotheses:

1. The provision of free NRT will increase quit attempts in Ontario smokers 2. The provision of free NRT will increase long-term quit rates (>/= 6 months) in Ontario smokers.

3. Smokers who quit smoking using NRT will have reduced health care costs after the first year of treatment.

 
Interventional
Treatment, Non-Randomized, Open Label, Single Group Assignment, Efficacy Study
Smoking
  • Drug: nicotine replacement
  • Behavioral: behavioural intervention
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Recruiting
10000
October 2007
March 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Subjects must be Ontario residents with valid OHIP cards
  • Older than or equal to 18 years of age
  • Current daily/near daily smokers who smoke >10 cigarettes per day
  • Smoked more than 100 cigarettes in their lifetime
  • Willing to provide informed consent to link Personal Health information and utilization of health care services

Exclusion Criteria:

  • Current treatment with Varenicline
  • Allergic to adhesive
  • Intolerant to Nicotine Replacement Therapy
  • Medical contraindication as determined by the attending physician of the patient or study physician
Both
18 Years and older
No
Contact: Peter Selby, MD, MHSc 416-535-8501 ext 6859 peter_selby@camh.net
Contact: Laurie Zawertailo, PhD laurie_zawertailo@camh.net
Canada
 
NCT00356993
Dr. Peter Selby, Centre for Addiction and Mental Health
81/2005
Centre for Addiction and Mental Health
  • Pfizer
  • Ontario Ministry of Health and Long Term Care
Principal Investigator: Peter Selby, MD, MHSc Centre for Addiction and Mental Health
Centre for Addiction and Mental Health
February 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP