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Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)

This study has been completed.
Sponsor:
Collaborator:
Northwestern University
Information provided by:
Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT00353795
First received: July 18, 2006
Last updated: May 25, 2010
Last verified: September 2009
History of Changes

July 18, 2006
May 25, 2010
July 2005
June 2008   (final data collection date for primary outcome measure)
Mean Coronary Wall Thickness [ Time Frame: n/a (cross sectional analysis) ] [ Designated as safety issue: No ]
Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).
Coronary artery wall thickness
Complete list of historical versions of study NCT00353795 on ClinicalTrials.gov Archive Site
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Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)
Coronary Atherosclerosis Evaluation by Arterial Wall MRI

The overall goal of this study is to use MRI to:

  • Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
  • Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
  • Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes
Interventional
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Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
  • Coronary Arteriosclerosis
  • Arteriosclerosis, Coronary
  • Atherosclerosis, Coronary
  • Coronary Artery Disease
  • Coronary Atherosclerosis
Procedure: MR Imaging of the Coronary Arteries
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
179
June 2008
June 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
  • Male or Female adult equal to or older than 45 years of age
  • Willing/able to provide informed consent

Exclusion Criteria:

  • Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
  • Metal in the eyes
Both
45 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00353795
05-05-23-01, 5R01HL078909
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Johns Hopkins University
Northwestern University
Principal Investigator: David A Bluemke, MD PhD Johns Hopkins University
Johns Hopkins University
September 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP