The purpose of this study is to evaluate the effects of multiple doses of DVS SR and paroxetine on the pharmacokinetics of a single dose of desipramine in healthy subjects.

• Drug: desvenlafaxine SR
• Drug: desipramine
• Drug: paroxetine

Inclusion Criteria:

• Healthy men and women between 18 to 55 years of age
• Healthy as determined by the investigator on the basis of medical history and physical examination, laboratory test results, vital signs, and 12-lead electrocardiogram (ECG)
• History of being a nonsmoker for at least 1 year Other inclusions apply.

Exclusion Criteria:

• Presence or history of any disorder or significant cardiovascular, hepatic, renal, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, or neurologic condition, and any severe conditions of the ears, eyes or throat (such as glaucoma or increased intraocular pressure) or psychiatric disease
• Known or suspected alcohol abuse or consumption of more than 2 standard units per day within the past 6 months
• Use of any over-the-counter, prescription, hormonal therapy or investigational medications within 30 days of study day-1 until the end of the study Other exclusions apply.