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Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by Rikshospitalet University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Rikshospitalet University Hospital
ClinicalTrials.gov Identifier:
NCT00328900
First received: May 22, 2006
Last updated: May 31, 2012
Last verified: April 2007
History of Changes

May 22, 2006
May 31, 2012
January 2006
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Number of skin conductance fluctuations
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Complete list of historical versions of study NCT00328900 on ClinicalTrials.gov Archive Site
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Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine
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24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.

Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.

Study hypothesis: SC is not influenced by i.v. administration of atropine.
Interventional
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Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Prevention
  • Hemorrhoids
  • Fissure in Ano
  • Drug: Administration of 0,7 mg of atropine
  • Device: Measurement of skin conductance with Pain detector
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
24
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Inclusion Criteria:

  • Patients in ASA-group 1-2
  • Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour
  • informed consent
  • BMI <30

Exclusion Criteria:

  • Patients using any medication known to influence the autonomous nervous system
  • Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)
  • BMI >30
  • Pregnancy
Both
18 Years and older
No
Contact: Hanne Storm, PhD +47 23074398 hanne.storm@medisin.uio.no
Norway
 
NCT00328900
S-03113
No
Hanne Storm MD.PhD, Rikshospitalet, UIO
Rikshospitalet University Hospital
Not Provided
Study Director: Hanne Storm, PhD Rikshospitalet University Hospital
Rikshospitalet University Hospital
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP