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Antibiotic Resistant Community-Acquired E. Coli

This study is currently recruiting participants.
Study NCT00298103.   Last updated on June 3, 2008.   Information provided by University of Pittsburgh

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Descriptive Information Fields
Brief Title  Antibiotic Resistant Community-Acquired E. Coli
Official Title  Antibiotic Resistant Community-Acquired E. Coli
Brief Summary

The purpose of this study is to review patients with E. coli infections at UPMC from January 1, 2004 to December 31, 2005 to determine if these infections have arisen in the community rather than in hospitals or nursing homes. The occurrence of such resistant isolates could be devastating if they were associated with bloodstream infection, such as sometimes accompanies urinary tract infection, since antibiotic resistant E. coli is not suspected in isolates coming from the community.

Detailed Description

The following variables will be followed: age, sex, hospital location at the time of positive culture (ER, medical ward, ICU etc), prior hospitalization or nursing home admission, receipt of outpatient dialysis or other regular medical care (eg, outpatient chemotherapy), presence of invasive devices, receipt of antibiotics, including their type and whether they were adequate for the resistance profile of the organism, prior positive microbiologic cultures.

Study Phase
Study Type  Observational
Study Design  Other, Retrospective
Primary Outcome Measure 
Secondary Outcome Measure 
Condition  E Coli Infection
Antibiotic Resistant
Intervention 
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status  Recruiting
Enrollment  1000
Start Date  February 2006
Completion Date December 2012
Eligibility Criteria 

Inclusion Criteria:

  • ll patients with E. coli infections during the time period of the study will be reviewed. A community-associated E. coli isolate will be defined as one which was recovered from a clinical culture from a patient at UPMC-P who had no established risk factors for infection with an antibiotic resistant organism.

Established risk factors are defined as:

  • Isolation of the organism two or more days after admission for hospitalization OR A history of hospitalization, surgery, dialysis, or residence in a long-term care facility within one year before the culture date
  • OR The presence of an indwelling catheter or percutaneous medical device (eg, tracheostomy tube, gastrostomy tube, or Foley catheter) at the time of the culture
  • OR Previous isolation of an antibiotic resistant organism
Gender Both
Ages
Accepts Healthy Volunteers No
Contacts ††
Contact: David L Paterson, MD     412-648-6401     patersond@dom.pitt.edu    
Contact: Diana Lynn Pakstis, RN, BSN     412-648-6553     pakstisdl@dom.pitt.edu    
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00298103
Organization ID IRB# 0602065
Secondary IDs ††
Study Sponsor  University of Pittsburgh
Collaborators †† Physicians own funding
Investigators 
Principal Investigator:     David L Paterson, MD     University of Pittsburgh    
Information Provided By University of Pittsburgh
Verification Date June 2008
First Received Date  February 27, 2006
Last Updated Date June 3, 2008

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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