Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2006 by Lawson Health Research Institute.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Lawson Health Research Institute
ClinicalTrials.gov Identifier:
NCT00294606
First received: February 17, 2006
Last updated: NA
Last verified: February 2006
History: No changes posted

February 17, 2006
February 17, 2006
February 2006
Not Provided
Myocardial ischemia measures by transesophageal echocardiography and ST segment analyses
Same as current
No Changes Posted
Myocardial ischemia measures by cardiac troponin I
Same as current
Not Provided
Not Provided
 
Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery
Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Cross-Clamping During Carotid Endarterectomy Under General Anesthesia

This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
  • Vasopressor Agents
  • Endarterectomy, Carotid
  • Echocardiography, Transesophageal
Drug: Comparison of Effects of Phenylephrine and Norepinephrine
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
86
February 2006
Not Provided

Inclusion Criteria:

  • Elective carotid endarterectomy under general anesthesia
  • > 18 years old
  • Written informed consent

Exclusion Criteria:

  • Contraindication to general anesthesia
  • Contraindication to transesophageal anesthesia
  • esophageal disease
  • esophageal stricture
  • history of esophageal or gastric bleeding
  • esophageal anatomic abnormality
  • past esophageal or gastric surgery
  • severe dysphagia
Both
18 Years and older
No
Contact: Rosemary A Craen, MD, FRCPC (519) 663-3022 rosemary.craen@lhsc.on.ca
Contact: Hélène G Pellerin, MD, FRCPC (519) 663-3022 hpelleri@uwo.ca
Canada
 
NCT00294606
R-05-941
Not Provided
Not Provided
Lawson Health Research Institute
Not Provided
Principal Investigator: Rosemary A Craen, MD, FRCPC Associate Professor University of Western Ontario
Lawson Health Research Institute
February 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP