Identification of Cytokine Profiles and T Cell Subsets Among Immunosuppressed Patients at Risk of Developing Active Tuberculosis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2005 by Hvidovre University Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
Copenhagen Hospital Corporation
The Danish Rheumatism Association
The Danish Lung Association
Information provided by:
Hvidovre University Hospital
ClinicalTrials.gov Identifier:
NCT00285441
First received: January 31, 2006
Last updated: February 27, 2006
Last verified: December 2005

January 31, 2006
February 27, 2006
November 2005
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Complete list of historical versions of study NCT00285441 on ClinicalTrials.gov Archive Site
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Identification of Cytokine Profiles and T Cell Subsets Among Immunosuppressed Patients at Risk of Developing Active Tuberculosis
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The purpose of this study is to identify differences in TB specific immune responses among immunosuppressed patients latently infected with TB and patients with active TB.

Immunosuppressed patients latently infected with TB are at higher risk of developing active TB than patients with normal immune functions. Especially two patient categories are at risk: HIV positives and patients receiving TNF-a blocking medication. Existing methods of diagnosis and surveillance of latent TB infection can not identify who will develop active TB and who can control the infection. There is a need for better understanding of TB specific immune functions,as we believe deficient TB specific immune reactions is a key in reactivation of latent TB infection.

In this study we follow groups of latent TB infected patients with either rheumatoid arthritis or HIV. We follow the patients during treatment with TNF-a blocking medication, HAART treatment or prophylactic TB medication. Results are correlated to patients with active TB, latent TB and healthy controls.

Observational
Observational Model: Defined Population
Time Perspective: Longitudinal
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  • Tuberculosis
  • HIV Infections
  • Rheumatoid Arthritis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
60
September 2008
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Inclusion Criteria:

  • Latent TB infection + rheumatid arthritis
  • Latent TB infection + HIV
  • Active TB

Exclusion Criteria:

  • Age < 18yrs
  • Pregnancy
  • Patients not able to understand the given information
Both
18 Years and older
No
Contact: Morten Ruhwald, MD +45 36323632 mruhwald@mail.dk
Contact: Pernille Ravn, MD, Ph.d. +45 36323632 pravn@dadlnet.dk
Denmark
 
NCT00285441
KF-01-278477
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Hvidovre University Hospital
  • Copenhagen Hospital Corporation
  • The Danish Rheumatism Association
  • The Danish Lung Association
Principal Investigator: Morten Ruhwald, MD University Hospital Hvidovre
Hvidovre University Hospital
December 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP