Assessment of Myocardial Viability Using Multidetector Computed Tomography

This study has been completed.
Sponsor:
Collaborator:
Philips Medical Systems
Information provided by:
Rambam Health Care Campus
ClinicalTrials.gov Identifier:
NCT00285064
First received: January 30, 2006
Last updated: October 11, 2008
Last verified: February 2007

January 30, 2006
October 11, 2008
January 2006
August 2007   (final data collection date for primary outcome measure)
Prediction of viability from myocardial enhancement patterns
Same as current
Complete list of historical versions of study NCT00285064 on ClinicalTrials.gov Archive Site
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Assessment of Myocardial Viability Using Multidetector Computed Tomography
Non-Invasive Assessment of Myocardial Viability Using Multidetector Computed Tomography Post Acute Myocardial Infarction

To perform a comprehensive evaluation of multidetector CT myocardial enhancement patterns in patients with an acute ST elevation MI. In particular we plan to assess the relationship between regions with early hypoperfusion and/or late hyperenhancement, and myocardial viability.

20 patients admitted to ICCU with ST elevation MI, and treated with primary angioplasty on admission, will undergo between day 2 and 7 post-MI the following exams: a) multidetector CT: regular scan plus late scan at 10 minutes, to evaluate coronary arteries, regional function and myocardial enhancement, b) echocardiography with echo-contrast to evaluate function and size of abnormally contracting region and remodeling, c) nuclear studies: rest early and late Thallium SPECT, to evaluate perfusion and viability. At 3 months a second echo will be performed to assess recovery of abnormal segments. The perfusion defects on MSCT will be compared with the other modalities and at 3 months will be used to evaluate recovery of myocardial function i.e. viability. Parameters that will be evaluated include opacity of hypoenhanced segments, ratio of normal to abnormal segments, change in opacity between early and late scans, size and transmurality of hypoenhanced segments, and their relation to regional contraction.

Interventional
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Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind
Primary Purpose: Diagnostic
Myocardial Infarction
Procedure: CT
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
May 2008
August 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • acute ST elevation myocardial infarction
  • after primary angioplasty

Exclusion Criteria:

  • iodine allergy
  • renal failure
  • old MI
  • arrhythmia
  • inability to perform 20 second breath-hold
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Israel
 
NCT00285064
ram1099_CTIL
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Rambam Health Care Campus
Philips Medical Systems
Principal Investigator: Jonathan Lessick, MD DSc Rambam Health Care Campus
Rambam Health Care Campus
February 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP