Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2009 by The Parkinson's Institute.
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Information provided by:
The Parkinson's Institute
ClinicalTrials.gov Identifier:
NCT00282802
First received: January 26, 2006
Last updated: July 1, 2009
Last verified: July 2009

January 26, 2006
July 1, 2009
April 2001
Not Provided
Onset of Parkinson's disease [ Time Frame: duration of the project ] [ Designated as safety issue: No ]
Not Provided
Complete list of historical versions of study NCT00282802 on ClinicalTrials.gov Archive Site
Age of Parkinson's disease onset [ Time Frame: duration of the project ] [ Designated as safety issue: No ]
Not Provided
Not Provided
Not Provided
 
Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study
Twins and the Risk of PD: A Clinical and Imaging Study

The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.

Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.

The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins—at least one of whom has PD.

The overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.

The study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT—a nuclear imaging test involving blood flow to tissue—is used to evaluate certain brain functions.

Findings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample

Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort

Parkinson's Disease
Not Provided
1
National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
250
July 2010
Not Provided

Inclusion:

  • Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
Male
77 Years to 88 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00282802
R01NS40467, R01 NS 40467-01
No
Caroline M. Tanner, MD, PhD, Director of Clinical Research, The Parkinson's Institute
The Parkinson's Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Caroline M. Tanner, MD The Parkinson's Institute
The Parkinson's Institute
July 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP