Genetics of Recurrent Early Onset Major Depression

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2009 by National Institute of Mental Health (NIMH).
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:
NCT00260182
First received: November 28, 2005
Last updated: January 3, 2011
Last verified: May 2009

November 28, 2005
January 3, 2011
October 2005
June 2009   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00260182 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Genetics of Recurrent Early Onset Major Depression
Genetics of Recurrent Early Onset Major Depression

This study will identify specific genes that may cause a predisposition to depression in some families.

Depression is a serious medical illness that is often difficult to diagnose and treat. Studies on patterns of depression within families suggest that inherited genes may cause a predisposition to the disorder. People with early onset depression often have more relatives with depression than people whose depression does not begin until later in life. It is likely that several interacting genes cause this tendency towards the disorder, rather than one specific gene. This study will serve to identify particular genes that may cause a susceptibility to depression in order to better understand the brain mechanisms involved with severe depression. In turn, this may aid in the development of new treatments for depression.

Participation in this observational study will entail one interview and one blood test. Participants will be interviewed, either in person or by telephone, about their personal and family psychiatric history. The blood sample will be collected at a time and location that is convenient for the participant. Participants may also be asked to invite other family members to participate in the study.

For information on a related study please follow this link:

http://clinicaltrials.gov/show/NCT00005914

Observational
Observational Model: Cohort
Time Perspective: Retrospective
Not Provided
Retention:   Samples With DNA
Description:

Blood samples with DNA

Non-Probability Sample

The study will include participants with a family history of depression.

Depression
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
1500
June 2009
June 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • History of recurrent major depression
  • Has a parent or sibling with a history of recurrent major depression
  • Depression began before the age of 31

Exclusion Criteria:

  • Bipolar I (manic-depressive) disorder
  • Schizophrenia
Both
21 Years to 70 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00260182
R01 MH061686-02, R01 MH059542, R01 MH059552, R01 MH075131, R01 MH059541, R01 MH060912, DNBBS 7G-GRR
Not Provided
GenRED Study, Stanford University
National Institute of Mental Health (NIMH)
Not Provided
Principal Investigator: Douglas F. Levinson, MD Stanford University
Principal Investigator: Myrna M. Weissman, PhD Columbia University/New York State Psychiatric Institute
Principal Investigator: J. Raymond DePaulo, MD Johns Hopkins University
Principal Investigator: William A. Scheftner, MD Rush University Medical Center
Principal Investigator: William Coryell, MD University of Iowa
Principal Investigator: William Lawson, MD Howard University
National Institute of Mental Health (NIMH)
May 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP