The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane

This study has been completed.
Sponsor:
Information provided by:
University Health Network, Toronto
ClinicalTrials.gov Identifier:
NCT00242671
First received: October 18, 2005
Last updated: August 3, 2010
Last verified: September 2006

October 18, 2005
August 3, 2010
October 2005
August 2008   (final data collection date for primary outcome measure)
Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score
Same as current
Complete list of historical versions of study NCT00242671 on ClinicalTrials.gov Archive Site
Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery
Same as current
Not Provided
Not Provided
 
The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane
The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane.

The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.

Not Provided
Interventional
Phase 3
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind
Primary Purpose: Treatment
Anesthesia
Procedure: Isocapnic Hyperponea
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
December 2008
August 2008   (final data collection date for primary outcome measure)

Inclusion criteria:

  1. Elective gynecological procedure
  2. ASA I-III
  3. Age 18-80 years
  4. Signed informed consent

Exclusion criteria:

  1. ASA IV
  2. Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol
  3. Active smoking, asthma or other history of hyper-reactive airway disease
  4. History of chronic obstructive lung disease limiting exercise
  5. History of angina, previous myocardial infarction, valvular heart disease, or heart surgery
  6. Presence of heart murmurs or neck bruits
  7. ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities,
  8. History of difficult airway access
  9. Pulmonary hypertension and/or right ventricle dysfunction
  10. History of bulous emphysema, and/or spontaneous pneumothorax
  11. History of alcohol or drugs abuse
  12. Known history of psychiatric illness and/or medications
  13. Patients that required postoperative mechanical ventilation for any reason
Female
18 Years to 80 Years
No
Contact information is only displayed when the study is recruiting subjects
Canada
 
NCT00242671
UHN REB 05-0299-AE
Not Provided
Rita Katznelson, Toronto General Hospital, University Health Network
University Health Network, Toronto
Not Provided
Principal Investigator: Rita Katznelson, MD Toronto General Hospital, University Health Network
University Health Network, Toronto
September 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP