The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2005 by Uniwersytet Mikolaja Kopernika w Toruniu.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Uniwersytet Mikolaja Kopernika w Toruniu
ClinicalTrials.gov Identifier:
NCT00204178
First received: September 13, 2005
Last updated: November 30, 2005
Last verified: August 2005

September 13, 2005
November 30, 2005
April 2003
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Complete list of historical versions of study NCT00204178 on ClinicalTrials.gov Archive Site
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The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney
The Role of Reactive Oxygen Species in Ischaemia-Reperfusion Injury of the Transplanted Kidney

Measurement of reactive oxygen species production and antioxidant system status before and directly after reperfusion of the transplanted kidney and influence of oxidant stress on kidney function in 2 and 6 weeks.

Oxidative stress is one of the most important factors in ischaemia-reperfusion injury to the transplanted organ. In kidney transplant recipients following factors were measured: glutathione level, activities of glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) and superoxide anion production by granulocytes in whole blood without and after the stimulation with zymosan.

Blood was sampled from peripheral vein (before reperfusion) and directly from renal vein (5 and 15 minutes after reperfusion).

Transplanted kidney function was evaluated by the incidence and length of Delayed Graft Function and serum creatinine level in 2 and 6 weeks after transplantation.

Observational
Observational Model: Defined Population
Time Perspective: Cross-Sectional
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Kidney Transplantation
Behavioral: Oxidative stress in kidney transplant recipients
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
60
September 2005
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Inclusion Criteria:

  • consecutive patients accepted for and undergoing cadaveric kidney transplantation

Exclusion Criteria:

  • no informed consent
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Poland
 
NCT00204178
KB/38/2003
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Uniwersytet Mikolaja Kopernika w Toruniu
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Study Director: Zbigniew Wlodarczyk, MD,PhD Klinika Transplantologii Collegium Medicum UMK w Toruniu
Uniwersytet Mikolaja Kopernika w Toruniu
August 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP