Efficacy of Pre- and Post-Operative Oral Dextromethorphan

This study has been completed.
Sponsor:
Information provided by:
Khon Kaen University
ClinicalTrials.gov Identifier:
NCT00199303
First received: September 12, 2005
Last updated: NA
Last verified: July 2002
History: No changes posted

September 12, 2005
September 12, 2005
December 2002
Not Provided
  • Mean morphine consumption
  • Mean pain score
Same as current
No Changes Posted
Not Provided
Not Provided
Not Provided
Not Provided
 
Efficacy of Pre- and Post-Operative Oral Dextromethorphan
Efficacy of Pre- and Post-Operative Oral Dextromethorphan for Reduction of Intra- and 24-Hr Post-Operative Morphine Consumption for Transabdominal Hysterectomy

We studied the effect of dextromethorphan (DEX), an N-methyl-d-aspartate antagonist, on analgesic consumption and pain scoring after abdominal hysterectomy. Our aim was to compare the analgesic effectiveness and incidence of adverse side effects of oral DEX with placebo (P)

One hundred patients were randomized to two groups. Group DEX was given 30 mg tablets of oral dextromethorphan with their pre-medication and three more times in the first 24 hours after surgery. Group P received the placebo following the same schedule. Post-operative analgesic requirements were assessed using a patient-controlled analgesia system.

Pain was assessed at rest using a visual analog scale in the post anesthetic care unit(PACU), 6 and 24 hours after surgery.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
  • Efficacy of Dextromethorphan
  • Morphine Consumption
  • Pain
Drug: pre-operatively followed by 30 mg three times per day after surgery
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
100
December 2003
Not Provided

Inclusion Criteria:

  • women aged between 30 and 60, with an ASA physical status of I or II, undergoing elective total abdominal hysterectomy under general anesthesia.

Exclusion Criteria:

  • Women with a history of significant renal or hepatic impairment, allergy to any of the study medications, antitussive or NSAID use (48 hours or 1 week, respectively) before surgery, chronic pain and regular analgesic use, were excluded. Patients taking medications that could interact with dextromethorphan, including quinidine, flecainide, mexiletine, fluoxetine, amitriptyline, nortriptyline, and propafenone
Female
30 Years to 60 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Thailand
 
NCT00199303
efficacy of dextromethorphan, KhonKaen University
Not Provided
Not Provided
Khon Kaen University
Not Provided
Study Chair: waraporn chau-in, Asso Prof. Department of Anesthesiology, Faculty of Medicine,KhonKaen University,KhonKaen 40002, Thailand
Principal Investigator: BUSABONG SUKMOUEN, Dr. Department of Anesthesiology
Principal Investigator: KRIANGSAK NGAMSANGSIRISAPT, Dr. Department of Anesthesiology
Principal Investigator: WINITA JIRARAREUNGSAK Department of Anesthesiology
Khon Kaen University
July 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP