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| Descriptive Information Fields | |||||||||
| Brief Title † | Early Assessment of Anthracycline-Induced Cardiotoxicity (CARDIOTOX) | ||||||||
| Official Title † | Early Assessment of Anthracycline-Induced Cardiotoxicity: Usefulness of Biochemical Markers and Ventricular Function Assessment. | ||||||||
| Brief Summary | Anthracycline-based chemotherapy is a key point of the treatment of patients with Hodgkin's and non-Hodgkin's lymphomas. However, cumulative doses are limited by cardiotoxicity, resulting in a marked left ventricular function impairment that may lead to heart failure. The standard clinical approach to monitoring for anthracycline cardiotoxicity is based on cardiac function monitoring using echocardiography or radionuclide angiography. The aim of this study is to evaluate the usefulness of biochemical markers of cardiac injury (troponin and NT-proBNP) and structural changes on cardiac MR in predicting anthracycline cardiotoxicity. |
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| Detailed Description | |||||||||
| Study Phase | |||||||||
| Study Type † | Observational | ||||||||
| Study Design † | Screening, Longitudinal, Defined Population, Prospective Study | ||||||||
| Primary Outcome Measure † | |||||||||
| Secondary Outcome Measure † | |||||||||
| Condition † | Lymphoma Heart Failure, Congestive |
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| Intervention † | |||||||||
| MEDLINE PMIDs | 12075738, 9744975, 11279304, 12673177 | ||||||||
| Links | |||||||||
| Recruitment Information Fields | |||||||||
| Recruitment Status † | Not yet recruiting | ||||||||
| Enrollment † | 40 | ||||||||
| Start Date † | October 2005 | ||||||||
| Completion Date | |||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 18 Years to 70 Years | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | France | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00195897 | ||||||||
| Organization ID | 2005-001-CHB | ||||||||
| Secondary IDs †† | |||||||||
| Study Sponsor † | Centre Henri Becquerel | ||||||||
| Collaborators †† | Ligue contre le Cancer | ||||||||
| Investigators † |
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| Information Provided By | Centre Henri Becquerel | ||||||||
| Verification Date | September 2005 | ||||||||
| First Received Date † | September 12, 2005 | ||||||||
| Last Updated Date | September 12, 2005 | ||||||||
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