Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2010 by Weill Medical College of Cornell University.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
Information provided by:
Weill Medical College of Cornell University
ClinicalTrials.gov Identifier:
NCT00195052
First received: September 14, 2005
Last updated: September 21, 2010
Last verified: September 2010

September 14, 2005
September 21, 2010
May 2002
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Complete list of historical versions of study NCT00195052 on ClinicalTrials.gov Archive Site
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Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients
Intraoperative Optical Imaging Mapping of Neocortical Epilepsy in Human

Epilepsy is a disease affecting 1-2% of the population. Currently, the only known cure for epilepsy is surgery, which is much more effective at eliminating seizures arising from the medial temporal lobe compared with the neocortex. The problem with neocortical epilepsy is that the population of neurons underlying each epileptiform discharge varies over time. In addition, the spatial relationship between interictal events and the ictal onset zones, which are critical in defining the region of epileptogenesis, is not well understood and essential to the surgical treatment of epilepsy. Electrophysiological recording methods, although currently the "gold standard" in mapping epilepsy, are inadequate to address these questions based on restrictions due to volume conduction or sampling limitations. Optical recording techniques can overcome many of these limitations by sampling large areas of cortex simultaneously to provide information about blood flow, metabolism and extracellular fluid shifts that are intimately related to excitatory and inhibitory neuronal activity. In fact, optical recordings may actually be more sensitive to certain aspects of epileptic activity than electrophysiologic recordings. The goal will be to translate these findings into the operating room and map human neocortical epilepsy with the same optical techniques. Outcome following surgical resections to treat neocortical epilepsy will be correlated with the optical maps to determine the utility of intrinsic signal imaging in guiding brain surgery. These experiments will set the groundwork for implementing optical recordings in general clinical practice as a novel technique for mapping and predicting human seizures.

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Observational
Observational Model: Case-Only
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Non-Probability Sample

The patient, who is going to undergo a neurosurigcal procedure which will require intraoperative brain mapping to determine the brain organization, is the potential study subject.

Epilepsy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
40
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Inclusion Criteria:

  • patients with medically intractable epilepsy, between 18-65 ages

Exclusion Criteria:

-

Both
18 Years to 65 Years
No
Contact: Theodore H Schwartz, MD 212-746-5620 schwarh@med.cornell.edu
Contact: Hongtao Ma, Ph.D. 212-746-5516 hom2001@med.cornell.edu
United States
 
NCT00195052
0102004808
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Theodore H. Schwartz, The Newyork-Presbyterian hospital-Weill Cornell Medical College of Cornell University
Weill Medical College of Cornell University
  • National Institutes of Health (NIH)
  • National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Theodore H Schwartz, MD Weill Cornell Medical College/New York Presbyterian Hospital
Weill Medical College of Cornell University
September 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP