Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma

This study has been completed.
Sponsor:
Collaborator:
Sandler Family Supporting Foundation
Information provided by:
University of California, San Francisco
ClinicalTrials.gov Identifier:
NCT00187499
First received: September 13, 2005
Last updated: April 2, 2008
Last verified: September 2005

September 13, 2005
April 2, 2008
October 2002
Not Provided
Methacholine responsiveness
Same as current
Complete list of historical versions of study NCT00187499 on ClinicalTrials.gov Archive Site
  • gene expression in brushed epithelial cells
  • lung function
Same as current
Not Provided
Not Provided
 
Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma
Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma

The purpose of this study is to determine whether an inhaled corticosteroid (fluticasone) alters the expression of any gene expressed in the lining of the airways of asthmatics. The study uses high density gene chips which allow the study investigators to measures all gene in the human genome. We hypothesize that this approach will identify novel genes that are affected by steroids in asthmatics.

This is a 10 week, randomized, double blind, prospective study comparing the effects of inhaled fluticasone or inhaled placebo on measures of airway function, airway remodeling and airway gene expression in asthmatic subjects. Enrollment has been completed as have all study visits. We are now in the data analysis phase. The study design was as follows: Following a one-week run-in/characterization period, subjects were randomized to receive 2 puffs BID of fluticasone (250µg/puff) or matching placebo for 8 weeks. Beginning with the run-in period, subjects recordes in a daily diary their peak flow measurements twice daily, (symptoms of cough, sputum production, wheeze, dyspnea, and chest tightness. They visited the laboratory for an interval diary review and spirometry and for medication dispensing. Bronchoscopy was performed at baseline (week 1 of the run-in), and 1 week after starting the study drug Weekly telephone contact will be made during the treatment period to monitor subject well being and to ensure compliance with study medication. There was a one-week run-out to allow monitoring of subjects after discontinuation of the study drug.

Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Asthma
Drug: Inhaled fluticasone 500 ug BID for 8 weeks
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
February 2005
Not Provided

Inclusion Criteria:

  • Male and female patients with a history of asthma between the ages of 18 and 70 years.
  • PC20FEV1 Methacholine ≤ 8.0 mg/mL.
  • At least one of the following symptoms, beta agonist use, or FEV1 criteria:
  • Asthma symptoms on at least two days per week or Beta agonist use on at least two days per week or FEV1 < 85% predicted
  • Subjects must be non-smokers (patients who have never smoked or patients who have not smoked for 1 year and have a total pack-year smoking history < 15 packs).

Exclusion Criteria:

  • History of oral or inhaled steroid use in the past 4 weeks.
  • FEV1 < 60% predicted.
  • Lung disease other than asthma.
  • Patients with a history of a respiratory tract infection in the 4 weeks preceding the study.
  • Patients who have experienced a significant exacerbation in their asthma in the 6 weeks prior to the study.
  • Patients receiving hyposensitization therapy with the exception of those who are on a stable dose for the last three months.
  • Patients with cardiovascular disease (active) peptic ulcer disease or diabetes mellitus.
  • Females who are lactating or who are pregnant.
Both
18 Years to 70 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00187499
H6788-20160-04, P50HL56385
Not Provided
Not Provided
University of California, San Francisco
Sandler Family Supporting Foundation
Principal Investigator: John V Fahy, M.D. University of California, San Francisco
University of California, San Francisco
September 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP