Blockade of Vascular Potassium Channels During Human Endotoxemia - Tabular View

Home

Study Topics

Glossary


	Full Text View


	Tabular View


	Contacts and Locations


	No Study Results Posted


	Related Studies

Blockade of Vascular Potassium Channels During Human Endotoxemia

This study has been completed.

Study NCT00185003. Last updated on October 16, 2008. Information provided by Radboud University

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

Blockade of Vascular Potassium Channels During Human Endotoxemia

Official Title ^†

Blockade of Vascular Potassium Channels During Human Endotoxemia

Brief Summary

Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Detailed Description

Study Phase

Phase I

Study Type ^†

Interventional

Study Design ^†

Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Pharmacokinetics/Dynamics Study

Primary Outcome Measure ^†

Hemodynamics [ Time Frame: 24 hrs after LPS administration ]
Markers of Inflammation [ Time Frame: 24 hrs after LPS administration ]
Cytokines [ Time Frame: 24 hrs after LPS administration ]
Markers of Renal Injury [ Time Frame: 24 hrs after LPS administration ]
Inducible NO synthase expression [ Time Frame: 24 hrs after LPS administration ]
NO-metabolites [ Time Frame: 24 hrs after LPS administration ]
Mediators of Vascular reactivity [ Time Frame: 24 hrs after LPS administration ]
Sensitivity to norepinephrine [ Time Frame: 24 hrs after LPS administration ]

Secondary Outcome Measure ^†

Condition ^†

Endotoxemia

Intervention ^†

Drug: endotoxin
Drug: Potassium channel blockers: TEA, Quinin, Tolbutamide
Drug: L-NMMA

MEDLINE PMIDs

16864730

Links

Recruitment Information Fields

Recruitment Status ^†

Completed

Enrollment ^†

Start Date ^†

January 2003

Completion Date

June 2005

Eligibility Criteria ^†

Inclusion Criteria:

healthy volunteers

Exclusion Criteria:

drug, alcohol, nicotine abuse

Gender

Both

Ages

18 Years to 35 Years

Accepts Healthy Volunteers

Yes

Contacts ^††

Location Countries ^†

Administrative Information Fields

NCT ID ^†

NCT00185003

Organization ID

PP02

Secondary IDs ^††

ZONMW grant 907-00-056

Study Sponsor ^†

Radboud University

Collaborators ^††

ZonMw: The Netherlands Organisation for Health Research and Development

Investigators ^†

Principal Investigator:

Peter Pickkers, MD, PhD

Radboud University

Information Provided By

Radboud University

Verification Date

April 2008

First Received Date ^†

September 13, 2005

Last Updated Date

October 16, 2008

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.