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| Tracking Information | |||||||||
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| First Received Date ICMJE | September 13, 2005 | ||||||||
| Last Updated Date | May 28, 2009 | ||||||||
| Start Date ICMJE | June 2001 | ||||||||
| Estimated Primary Completion Date | June 2016 (final data collection date for primary outcome measure) | ||||||||
| Current Primary Outcome Measures ICMJE | |||||||||
| Original Primary Outcome Measures ICMJE | |||||||||
| Change History | Complete list of historical versions of study NCT00182949 on ClinicalTrials.gov Archive Site | ||||||||
| Current Secondary Outcome Measures ICMJE | |||||||||
| Original Secondary Outcome Measures ICMJE | |||||||||
| Descriptive Information | |||||||||
| Brief Title ICMJE | Genetics of Aging-Associated Conditions in Sardinia | ||||||||
| Official Title ICMJE | Genetics and Epidemiology of Aging-Associated Traits in the Sardinian Population (SardiNIA) | ||||||||
| Brief Summary | The purpose of this study is to examine the genetic risk factors for aging associated conditions. |
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| Detailed Description | To simplify the genetic study of risk factors for aging-associated conditions, the Sardinian "founder population" is being used, which has developed to a large modern population over thousands of years without appreciable admixture from without, so that the genetic heterogeneity is relatively reduced. A cohort of 6,000 participants has been enrolled from a cluster of 4 towns. Family history, epidemiological data, and measures of 98 quantitative traits, including cardiovascular risk factors and facets of personality, have been collected. The study is now continuing with longitudinal studies, including second and third visits to repeat measures and add more traits. Full genome scans are being done with the goal of localizing and ultimately identifying genetic variants that account for 5% or more of the variance for each trait. |
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| Study Phase | |||||||||
| Study Type ICMJE | Observational | ||||||||
| Study Design ICMJE | Cohort, Prospective | ||||||||
| Condition ICMJE |
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| Intervention ICMJE | |||||||||
| Study Arms / Comparison Groups | Cohort comprises over 6,200 participants, aged 18-102, from a cluster of 4 towns in Sardinia | ||||||||
| Publications * | |||||||||
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* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline. |
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| Recruitment Information | |||||||||
| Recruitment Status ICMJE | Recruiting | ||||||||
| Estimated Enrollment ICMJE | 6000 | ||||||||
| Estimated Completion Date | June 2016 | ||||||||
| Estimated Primary Completion Date | June 2016 (final data collection date for primary outcome measure) | ||||||||
| Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 18 Years and older | ||||||||
| Accepts Healthy Volunteers | Yes | ||||||||
| Contacts ICMJE |
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| Location Countries ICMJE | Italy | ||||||||
| Administrative Information | |||||||||
| NCT ID ICMJE | NCT00182949 | ||||||||
| Responsible Party | David Schlessinger, Ph.D., National Institute on Aging | ||||||||
| Study ID Numbers ICMJE | AG0041 | ||||||||
| Study Sponsor ICMJE | National Institute on Aging (NIA) | ||||||||
| Collaborators ICMJE | |||||||||
| Investigators ICMJE |
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| Information Provided By | National Institute on Aging (NIA) | ||||||||
| Verification Date | May 2009 | ||||||||
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ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |
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