Pharmacokinetics of Curcumin in Healthy Volunteers

This study has been completed.
Sponsor:
Information provided by:
Massachusetts General Hospital
ClinicalTrials.gov Identifier:
NCT00181662
First received: September 12, 2005
Last updated: April 2, 2007
Last verified: April 2007

September 12, 2005
April 2, 2007
August 2005
Not Provided
Curcumin pharmacology
Same as current
Complete list of historical versions of study NCT00181662 on ClinicalTrials.gov Archive Site
  • Interactions between piperine and curcumin
  • Interactions between silybin and curcumin
Same as current
Not Provided
Not Provided
 
Pharmacokinetics of Curcumin in Healthy Volunteers
Evaluation of Naturally Occurring Inhibitors of UDP-Glucuronyltransferase on the Oral Bioavailability of Curcumin in Normal Healthy Volunteers

This study looks to describe the pharmacokinetics of curcumin delivered as a single oral dose in healthy female volunteers. The impact of piperine and silybin on the pharmacokinetics of curcumin is also studied.

Healthy volunteers are seen on three separate visits and receive 4 gm of curcumin as a single oral dose either alone or with piperine or with silybin. Serial timed blood draws then are collected for pharmacokinetic analysis.

Interventional
Not Provided
Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
Healthy
Drug: Curcumin
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
6
Not Provided
Not Provided

Inclusion Criteria:

  • Healthy volunteer
  • On no medications except for birth control pills
  • Signed informed consent

Exclusion Criteria:

  • Pregnant
  • Comorbid disease
Female
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00181662
2005P-000650, P50 CA105009-01
Not Provided
Not Provided
Massachusetts General Hospital
Not Provided
Principal Investigator: Michael Seiden, M.D., Ph.D. Massachusetts General Hospital
Massachusetts General Hospital
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP