Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury - Tabular View

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Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

This study is currently recruiting participants.

Study NCT00178295. Last updated on September 6, 2006. Information provided by University of Rochester

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

Official Title ^†

Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

Brief Summary

Treatment for brain cancer may include radiation therapy. Radiation therapy is the treatment of tumors with X-rays. This study is related to understanding the side effects of radiation treatment for brain tumors.

This study is being conducted by the University of Rochester Cancer Center to compare the extent of side effects of brain cancer treatment with changes in levels of blood proteins called cytokines.

Detailed Description

Study Phase

Study Type ^†

Observational

Study Design ^†

Natural History, Longitudinal, Defined Population, Prospective Study

Primary Outcome Measure ^†

Secondary Outcome Measure ^†

Condition ^†

Brain Neoplasm

Intervention ^†

Procedure: Radiation Therapy

MEDLINE PMIDs

Links

Recruitment Information Fields

Recruitment Status ^†

Recruiting

Enrollment ^†

Start Date ^†

Completion Date

Eligibility Criteria ^†

Inclusion Criteria:

Any patient who will be treated to the brain or spinal axis for a CNS tum Patients so treated will be stratified according to whether or not the hypo is included in the treatment fields.
Patients receiving external beam radiation to the brain may also be rece chemotherapy or interferon-beta. (Add. #1, 11-9-95)
Patients receiving high dose rate (stereotactic radiosurgery) are eligible.
Patients must sign a study specific informed consent meeting all federal a guidelines.
Patients of any age, including children, are eligible (Add. #3, 11/25/97).

Exclusion Criteria:

Patients who have a malignancy involving the hypothalamic-pituitary ax
Patients who are not treated with irradiation to the brain or spinal axis.

Gender

Both

Ages

Accepts Healthy Volunteers

Contacts ^††

Contact: Louis S Constine, MD

585-275-5622

Location Countries ^†

United States

Administrative Information Fields

NCT ID ^†

NCT00178295

Organization ID

URCC 11095

Secondary IDs ^††

Study Sponsor ^†

University of Rochester

Collaborators ^††

Investigators ^†

Study Chair:	Louis S Constine, MD	Universtiy of Rochester, Dept of Radiation Oncology
Study Chair:	Ralph Brasacchio, MD	University of Rochester, Department of Radiation Oncology
Study Chair:	Paul Okunieff, MD	University of Rochester, Department of Radiation Oncology

Information Provided By

University of Rochester

Verification Date

September 2006

First Received Date ^†

September 12, 2005

Last Updated Date

September 6, 2006

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.