Response of Topical Capsaicin in Alopecia Areata - Tabular View

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Response of Topical Capsaicin in Alopecia Areata

This study has been completed.

Study NCT00176969. Last updated on November 8, 2006. Information provided by University of Minnesota

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

Response of Topical Capsaicin in Alopecia Areata

Official Title ^†

Perifollicular Nerves in Alopecia Areata: Response to Topical Capsaicin

Brief Summary

It has been postulated that Alopecia Areata (AA) is, at least in part, a neurologically mediated disease. Research supporting this theory includes the finding that nerves surrounding the hair follicles are collapsed. We want to take this research a step further and show that not only are these perifollicular nerves collapsed, but that their function is also impaired.

Detailed Description

To assess the function of perifollicular scalp nerves in AA we will look at the response of these nerves to the topical medication capsaicin. Under normal circumstances topical capsaicin is known to target nerves in the peripheral nervous system causing short-term release of the neuropeptide Substance P (SP) as well as long-term transient depletion of SP. We expect the AA patients will respond abnormally to topical capsaicin treatment.

Study Phase

Phase IV

Study Type ^†

Interventional

Study Design ^†

Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Pharmacokinetics Study

Primary Outcome Measure ^†

Topical capsaicin will quantitatively decrease the amount of Substance P in the scalp of AA patients.

Secondary Outcome Measure ^†

The scalps of AA patients may be less sensitive to stimuli.

Condition ^†

Alopecia Areata

Intervention ^†

Drug: Capsaicin

MEDLINE PMIDs

Links

Recruitment Information Fields

Recruitment Status ^†

Completed

Enrollment ^†

Start Date ^†

August 1997

Completion Date

June 2000

Eligibility Criteria ^†

Inclusion Criteria:

Must have alopecia totalis or universalis.
Be in good health.
Not be taking any medications including topical medications
Be 18 years or older.
Be willing to apply study medication or vehicle as directed, comply with instructions and commit to follow-up visits.
Not have had hair chemically treated (including colored hair, permed hair, etc) within the month prior to the study.

Exclusion Criteria:

Absence of extensive alopecia areata.
People not in good health.
People taking medications.
Allergies to capsaicin.
Presence of irritated or visibly inflamed scalp.
Having had hair chemically treated (including colored hair, permed hair, etc.) within the month prior to study.

Gender

Both

Ages

18 Years to 70 Years

Accepts Healthy Volunteers

Yes

Contacts ^††

Location Countries ^†

United States

Administrative Information Fields

NCT ID ^†

NCT00176969

Organization ID

9707M00122

Secondary IDs ^††

Study Sponsor ^†

Hordinsky, Maria K., MD

Collaborators ^††

Investigators ^†

Principal Investigator:	Maria Hordinsky, MD	University of Minnesota
Principal Investigator:	Marna Ericson, Ph D	University of Minnesota

Information Provided By

University of Minnesota

Verification Date

November 2006

First Received Date ^†

September 12, 2005

Last Updated Date

November 8, 2006

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.