Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Zakiya Rice, Emory University
ClinicalTrials.gov Identifier:
NCT00166192
First received: September 13, 2005
Last updated: November 12, 2013
Last verified: November 2013

September 13, 2005
November 12, 2013
January 2008
January 2010   (final data collection date for primary outcome measure)
Clinical efficacy by clinician's evaluation [ Time Frame: 3 months ] [ Designated as safety issue: No ]
Hyperpigmenation Global Score
Clinical efficacy by clinician's evaluation
Complete list of historical versions of study NCT00166192 on ClinicalTrials.gov Archive Site
Efficacy by subject's evaluation [ Time Frame: 3 months ] [ Designated as safety issue: No ]
Hyperpigmentation Global Score
Efficacy by subject's evaluation
Not Provided
Not Provided
 
Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid
Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Not Provided
Interventional
Phase 4
Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Melasma
  • Procedure: Jessner's solution chemical peel
  • Procedure: Trichloroacetic acid chemical peel
Active Comparator: Chemical Peel
Split face treatment paradigm
Interventions:
  • Procedure: Jessner's solution chemical peel
  • Procedure: Trichloroacetic acid chemical peel
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
19
November 2013
January 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Adults > 18 years old
  • Clinical diagnosis of melasma
  • Mental capacity to give informed consent

Exclusion Criteria:

  • Pregnancy
  • H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone
  • Active dermatitis
  • Presence of cutaneous infection
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00166192
IRB00024850
Yes
Zakiya Rice, Emory University
Emory University
Not Provided
Principal Investigator: Carl Washington, MD Emory University Department of Dermatology
Emory University
November 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP