The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients - Tabular View

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The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

This study has been terminated.

Study NCT00164814. Last updated on March 25, 2008. Information provided by Chinese University of Hong Kong

This Tabular View shows the required WHO registration data elements as marked by ^†

Descriptive Information Fields

Brief Title ^†

The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

Official Title ^†

Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pian in Chinese? Part I: The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients

Brief Summary

Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease. Despite its benign nature, this condition causes anxiety, impairs quality of life and consumes a substantial amount of healthcare resources. While acid reflux and motility disorder in the esophagus are often attributed as the cause of NCCP, visceral hyperalgesia of esophagus is now recognized to play a central role in the pathogenesis of this condition. This research project aims to evaluate the role of visceral hyperalgesia in Chinese patients with NCCP. NCCP patients will be evaluated for the prevalence of gastroesophageal reflux disease and esophageal motility disorder by endoscopy, manometry and pH study. The visceral sensory and pain thresholds of these patients will be compared with asymptomatic controls.

Detailed Description

Study Phase

Study Type ^†

Observational

Study Design ^†

Prospective

Primary Outcome Measure ^†

Secondary Outcome Measure ^†

Condition ^†

Non-Cardiac Chest Pain

Intervention ^†

MEDLINE PMIDs

Links

Recruitment Information Fields

Recruitment Status ^†

Terminated

Enrollment ^†

100

Start Date ^†

Completion Date

Eligibility Criteria ^†

Inclusion Criteria:

Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy
Age between 18-70

Exclusion Criteria:

Gastroesophageal reflux disease
Psychiatric illness
Cerebrovascular accident
Active peptic ulceration
Heart failure or cardiac bradyarrhythmia
Epilepsy
Pregnancy or lactating female
Previous hypersensitivity to muscle relaxant

Gender

Both

Ages

18 Years to 70 Years

Accepts Healthy Volunteers

Yes

Contacts ^††

Location Countries ^†

China

Administrative Information Fields

NCT ID ^†

NCT00164814

Organization ID

NPA study

Secondary IDs ^††

Study Sponsor ^†

Chinese University of Hong Kong

Collaborators ^††

Investigators ^†

Principal Investigator:

Justin CY WU, MD

Chinese University of Hong Kong

Information Provided By

Chinese University of Hong Kong

Verification Date

March 2008

First Received Date ^†

September 9, 2005

Last Updated Date

March 25, 2008

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.